2014, Pages 535–555
18 – Safe African Medicinal Plants for Clinical Studies
Medicinal
plants have been the basis of treatment of various diseases in African
traditional medicine as well as other forms of treatment from diverse
cultures of the world. About 80% of the world’s population still depends
solely on traditional or herbal medicine for treatment of diseases,
mostly in Africa and other developing nations. Most of the potent
medicinal plants have relatively no toxic or adverse effects when used
by humans, while some are very toxic to both humans and animals with the
potential of damaging certain organs in the body. This calls for
caution in the use of medicinal plants of which the use is presently on
the increase due to easy availability, affordability, accessibility, and
promising efficacy comparable to the often high cost and adverse
effects of standard synthetic drug agents. This chapter highlights some
safe medicinal plants with good toxicological profile in laboratory
animals and/or cell culture experiment that are qualified for clinical
trials in humans. Several medicinal plants were evaluated for their good
toxicological profile using online research. After much screening, only
those medicinal plants without serious toxic effects in animals and
cell culture experiments were chosen and precisely discussed.
Keywords
- African medicinal plants;
- safety;
- clinical trials;
- toxicity;
- animal studies
Copyright © 2014 Elsevier Inc. All rights reserved.