2015, Pages 993–1001
Chapter 92 – Ferulic Acid and Angelica archangelica Extract in Dementia: Effects on Cognitive Functions and Behavioral and Psychological Symptoms of Dementia
- Available online 10 November 2014
Symptoms
of dementia are classified as “cognitive disturbance” and “behavioral
and psychological symptoms of dementia.” Understanding how to inhibit
the progression of cognitive disturbance and control the behavioral and
psychological symptoms of dementia are the most important problems
associated with this disease. Ferulic acid is a nutrient that exists in
many kinds of grains, whereas Angelica archangelica is a biennial plant from the umbelliferous family Apiaceae. Our studies have shown that treatment with ferulic acid and A. archangelica
extract suppressed the development of mild cognitive impairment in
dementia and also improved the behavioral and psychological symptoms of
frontotemporal lobar degeneration or dementia with Lewy bodies. There
were no adverse effects or significant changes in the physical findings
or laboratory data during treatment. Our findings suggest that ferulic
acid and A. archangelica extract is extremely safe and represents a useful therapeutic tool for patients with mild cognitive impairment and dementia.
Keywords
- Ferulic acid;
- Angelica archangelica;
- dementia;
- mild cognitive impairment;
- cognitive disturbance;
- behavioral and psychological symptoms of dementia
Copyright © 2015 Elsevier Inc. All rights reserved.
