Volume 109, January 2015, Pages 96–102
Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
Highlights
- •
- An 8,4′-oxyneolignan incorporating 2-hydroxyethylamine was isolated from F. hispida.
- •
- An acetoxy-substituted phenanthroindolizidine alkaloid was isolated from F. hispida.
- •
- Hispidacine induced vasorelaxation in rat isolated aorta.
- •
- Hispiloscine showed significant cytotoxicity against breast, lung and colon cancer cells.
Abstract
Hispidacine,
an 8,4′-oxyneolignan featuring incorporation of an unusual
2-hydroxyethylamine moiety at C-7, and hispiloscine, a
phenanthroindolizidine alkaloid, were isolated from the stem-bark and
leaves of the Malaysian Ficus hispida Linn. Their structures
were established by spectroscopic analysis. Hispidacine induced a
moderate vasorelaxant activity in rat isolated aorta, while hispiloscine
showed appreciable antiproliferative activities against MDA-MB-231,
MCF-7, A549, HCT-116 and MRC-5 cell lines.
Graphical abstract
Phytochemical investigation of a Malaysian sample of Ficus hispida
Linn. led to isolation of an unusual 8,4′-oxyneolignan-alkaloid,
hispidacine, and two phenanthroindolizidine alkaloids, hispiloscine and
(+)-deoxypergularinine. Hispidacine induced vasorelaxant activity in rat
aorta, while hispiloscine showed antiproliferative activities against
four human cancer cell lines.
Keywords
- Ficus hispida;
- Moraceae;
- Alkaloids;
- Neolignans;
- Phenanthroindolizidine;
- NMR;
- Antiproliferation;
- Vasorelaxation
- Corresponding author. Tel.:
+60 3 89248208; fax: +60 3 89248018.
Copyright © 2014 Elsevier Ltd. All rights reserved.
