Volume 173, 15 September 2015, Pages 251–255
Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract
Abstract
Ethnopharmmacological relevance
Aleurites moluccana
is a medicinal plant popularly used to treat pain, fever, asthma,
hepatitis, gastric ulcer and inflammatory process in general. Recently,
pre-clinical studies have demonstrated that the dry extract obtained
from A. moluccana leaves was effective as analgesic, anti-inflammatory and wound healing.
Aim
The
present study has aimed to evaluate the mechanisms involved in the
topical anti-inflammatory effects of the semisolid containing 10 mg/g of
A. moluccana dried extract.
Material and Methods
Ear
edema induced by croton oil (2.5%) in mice was used throughout the
study. The level of cytokines tumour necrosis factor (TNF) and
interleukine-1β (IL-1β) and chemokine keratinocyte chemoattractant
(CXCL1/KC), and neutrophil migration were quantified. The histological
analysis has also been performed.
Results
The
topical treatment with the semisolid was able to significantly inhibite
the ear edema (35.77±7.35%). This effect was accompanied by the
reduction of leukocyte migration, as well as TNF (53.75±12.96%), IL-1β
(38.36±5.92%), and CXCL1/KC (62.29±11.65%) decreased levels.
Conclusions
This
study demonstrated for the first time the mechanisms involved in the
topical anti-inflammatory effect presented by the semisolid containing A. moluccana
dried extract pointing as the main mechanism is the reduction in the
leukocyte migration and consequently resulting in diminished levels of
cytokins and chemokines, indicating this herbal product as a promissor
anti-inflammatory phytomedicine to treat skin inflammatory diseases.
Graphical abstract
Keywords
- Aleurites moluccana;
- Skin inflammation;
- Cytokines;
- Myeloperoxidase
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
