A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri

Natural Product Research

Volume 30, Issue 4, 16 February 2016, Pages 399-405

 (Article)

Suárez, A.I.^a , 

Mancebo, M.^a, 

Monache, F.D.^b, 

Tirri, M.M.^c, 

Sojo, F.^d, 

Arvelo, F.^d, 

Tillett, S.^a

 

^a  Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela

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Abstract

A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using ¹H and ¹³C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 M for the human tumour cell lines were observed for compound 2. © 2015 Taylor & Francis.

Author keywords

cytotoxicity; phenolic glycoside; Strychnos fendleri; strychnosinol

ISSN: 14786419 CODEN: NPRAASource Type: Journal Original language: English

DOI: 10.1080/14786419.2015.1019351Document Type: Article

Publisher: Taylor and Francis Ltd.