Cytotoxic and genotoxic effects of extracts from Annona montana M. fruit

Food and Agricultural Immunology

Volume 27, Issue 4, 3 July 2016, Pages 559-569

Bailon-Moscoso, N.^ab , 

Romero Benavides, J.C.^c, 

Ramirez Orellana, M.I.^b, 

Ojeda, K.^b, 

Granda, G.^b, 

Ratoviski, E.A.^b, 

Ostrosky-Wegman, P.^a

 

^a  Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Exterior, Coyoacán, Mexico
^b  Departamento de Ciencias de la Salud, Universidad Técnica Particular de Loja, San Cayetano s/n, CP 1101608, Loja, Ecuador

View additional affiliations

View references (38)

Abstract

Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment of dysentery. The aim of this study was to investigate whether hexane, ethyl acetate or methanol extracts of A. montana M. can be cytotoxic to human tumor cells or exhibit genotoxic effects on normal human cells. The organic extracts were shown to inhibit survival of tumor cells originating from human astrocytoma, breast, colon, lung and prostate cancers. Furthermore, they were found to induce DNA damage in normal human lymphocytes, as shown by comet assay. The genotoxic effects observed suggest that traditional folk medicines prepared from extracts of the immature fruit of A. montana should be used with caution. © 2016 Taylor & Francis.

Author keywords

Annona montana M; comet assay; cytotoxicity; genotoxicity

ISSN: 09540105 CODEN: FAIMESource Type: Journal Original language: English

DOI: 10.1080/09540105.2016.1148121Document Type: Article

Publisher: Taylor and Francis Ltd.