a Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
b Department of Rheumatology, Baqiyatallah University of Medical Sciences, Tehran, Iran
c Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
b Department of Rheumatology, Baqiyatallah University of Medical Sciences, Tehran, Iran
c Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Osteoarthritis (OA) is one of the most common musculoskeletal disorders all over the world. Available antiarthritic medications have only partial efficacy and their long-term use is associated with adverse events. Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. The present study evaluated the impact of two doses of EA extract compared with ibuprofen on the severity of disease in patients with knee OA. This study was designed as a randomized, double blind, active-controlled and parallel group trial. Patients with OA were randomized to receive 300 mg/day (n=33) or 600 mg/day (n=32) of EA aqueous extract, or 800 mg/day ibuprofen (n=32) for 7 weeks. EA extract contained 0.21% (w/w) kaempferol according to HPLC. Efficacy of treatment was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS) of pain, Lequesne’s Pain-Function Index (LPFI), and patient’s global assessment (PGA) index. The amount of kaempferol in the extract was determined by HPLC method to be 0.21% w/w. There were significant reductions in WOMAC, VAS, LPFI and PGA scores by the end of trial with all three interventions. Comparison of the changes in WOMAC, VAS and LPFI scores among the treatment groups did not reveal any significant difference between EA and ibuprofen, and between low and high doses of EA. EA was safe and well tolerated during the course of trial and no adverse event was reported. The present results suggest beneficial effects of aqueous EA extract in reducing the symptoms of OA with an efficacy comparable to that of ibuprofen. © 2016, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
Author keywords
Clinical trial; Elaeagnus angustifolia; NSAID; Osteoarthritis; Pain
ISSN: 16112156Source Type: Journal Original language: English
DOI: 10.17179/excli2015-639Document Type: Article
Publisher: Leibniz Research Centre for Working Environment and Human Factors
Sahebkar, A.; Biotechnology Research Center, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Iran; email:sahebkara@mums.ac.ir
© Copyright 2016 Elsevier B.V., All rights reserved.
© Copyright 2016 Elsevier B.V., All rights reserved.
