α-glucosidase inhibitors from Dendrobium tortile

Records of Natural Products

Volume 10, Issue 5, 1 September 2016, Pages 609-616

Open Access

  (Article)

Limpanit, R., 

Chuanasa, T., 

Likhitwitayawuid, K., 

Jongbunprasert, V., 

Sritularak, B. 

 

Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand 

View references (31)

Abstract

From the whole plant of Dendrobium tortile, a new compound, namely 4-(2-hydroxypropyl)-2(5H)-furanone, was isolated, together with six known compounds, which included trans-tetracosylferulate (2), cis-docosylferulate (3), p-hydroxybenzaldehyde (4), 3,4-dihydroxy-3,4 α -dimethoxybibenzyl (5), (2S)-eriodictyol (6) and dendrofalconerol A (7). The structures of these compounds were determined through analysis of 1-D and 2-D NMR and HR-ESI-MS data. All of the isolates were evaluated for their α -glucosidase inhibitory activity. Compound 7 showed strong α -glucosidase inhibitory activity when compared with the positive control acarbose, whereas compounds 5 and 6 exhibited appreciable effects. An enzyme kinetic study revealed that compound 7 is a non-competitive inhibitor of α -glucosidase. This is the first report of the chemical constituents with biological activity from D. tortile. © 2016 ACG Publications. All rights reserved.

Author keywords

2(5H)-furanone; Bisbibenzyl; Dendrobium tortile; Orchidaceae; α-glucosidase

ISSN: 13076167Source Type: Journal Original language: English

Document Type: Article

Publisher: ACG Publications

References (31)

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  Sritularak, B.; Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Thailand; email:boonchoo.sr@chula.ac.th
© Copyright 2016 Elsevier B.V., All rights reserved.