Investigation of anti-inflammatory and analgesic properties of methanolic extract of Costus speciosus seeds (Article)

International Journal of Pharmacognosy and Phytochemical Research

Volume 8, Issue 3, March 2016, Pages 524-530

Ansari, P.^ab, 

Chowdhury, A.^b, 

Quador, M.^d, 

Debnath, M.^a, 

Abdurahman, M.S.M.^b, 

Hossain, M.M.^e, 

Ahmed, I.H.^a, 

Naveed, J.M.^c, 

Rashid, M.M.U.^ab

 

^a  Department of Pharmaceutical Sciences, North South University, Block-B, Bashundhara R/A, Dhaka, Bangladesh
^b  Department of Pharmacy, International Islamic University Chittagong, 154/A, college road, Chittagong, Bangladesh
^c  Department of Pharmacy, Southeast University, 251/A, Tejgaon I/A, Dhaka, Bangladesh 

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Abstract

Propose We aimed to examine and evaluate the anti-inflammatory and analgesic property of the seeds of the traditionallyused medicinal plant of Bangladesh, Costus speciosus. Materials and Methods: Our investigation includes the evaluation of the phytochemical composition and both in vitro and in vivo analgesic and anti-inflammatory action of the methanolic extracts of Costus speciosus seeds (MECS). We have modified a little to examine the effect, including formalin induced paw edema and tail immersion process. Results: At the dosage of 500 mg/kg, the extract showed the maximum inhibitory effect on the paw,1 hour after the carrageenan administration, with inhibition of over 50%. The best inhibition (52.27±0.017%; p<0.0001) elicited by the extract was three hours after formalin injection. With the help of hotplate procedure evaluation, C. speciosus increased pain tolerance time up to 17.83±0.085 min, area the compared accredited diffuse acknowledgment time to 21.68±0.427 min. In appendage captivation acclimation the acknowledgment time used to be continued at 600 mg/kg by way of C. speciosus 4.49 ± 0.214 (p<0.0001) afterwards 2 hours of extract initiation. Conclusion: This experiment displays that the plant part is capable of inhibiting mediators, responsible for pain and inflammation and hence, the extract may be developed as an analgesic and anti-inflammatory agent by screening the molecule of interest, from the extract. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.

Author keywords

Analgesic; Anti-inflammatory; C. speciosus; HRBC; Inflammation; Protein denaturation

ISSN: 09754873Source Type: Journal Original language: English

Document Type: Article

Publisher: International Journal of Pharmacognosy and Phytochemical Research

References (38)

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  Ansari, P.; Department of Pharmaceutical Sciences, North South University, Block-B, Bashundhara R/A, Bangladesh
© Copyright 2016 Elsevier B.V., All rights reserved.