Neuroprotective Effect of Natural Products on Peripheral Nerve Degeneration: A Systematic Review

Neurochemical Research

Volume 41, Issue 4, 1 April 2016, Pages 647-658

Araújo-Filho, H.G.^a, 

Quintans-Júnior, L.J.^a, 

Barreto, A.S.^b, 

Almeida, J.R.G.S.^c, 

Barreto, R.S.S.^b, 

Quintans, J.S.S.^a 

 

^a  Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, São Cristóvão, SE, Brazil
^b  Department of Health Education, Federal University of Sergipe, São Cristóvão, SE, Brazil
^c  Department of Pharmaceutical Science, Federal University of Vale do São Francisco, Petrolina, PE, Brazil 

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Abstract

Peripheral nerve injury (PNI) is a serious public health problem that is linked with motor, sensory and autonomic deficits. Given the fact that this type of disorder leads to a decreased quality of life in most patients and adherence of available drugs is limited and have adverse effects, we investigated the efficacy of natural products in a PNI model. The search terms plants,medicinal, nerve regeneration, nerve crush, sciatic nerve as well as MeSH terms or free-text words were used to retrieve English language articles in PubMed, Scopus, Web of Science and LILACS published until July 2015. After sciatic nerve crush, natural products have improved significantly motor performance, sensory function and electrical conductance measured over weeks. Among the pharmacological targets suggested by the action of natural products, there were citations on the activation of the antiapoptotic signaling pathway, modulation in the expression of pro-inflammatory cytokines and neurotrophic factors. The systematic review provides scientific evidence that natural products are pharmacologically effective in the treatment of PNI such as sciatic nerve crush. © 2015, Springer Science+Business Media New York.

Author keywords

Medicinal plant; Natural products; Nerve regeneration; Peripheral nerve injury; Sciatic nerve crush

ISSN: 03643190 CODEN: NEREDSource Type: Journal Original language: English

DOI: 10.1007/s11064-015-1771-2Document Type: Review

Publisher: Springer New York LLC

References (111)

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  Quintans, J.S.S.; Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, Brazil; email:jullyanaquintans@gmail.com
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