Potential biomarkers for esophageal cancer

SpringerPlus

Volume 5, Issue 1, 1 December 2016, Article number 467

Open Access

  (Review)

Tan, C. , 

Qian, X. , 

Guan, Z. , 

Yang, B. , 

Ge, Y. , 

Wang, F. , 

Cai, J. 

 

Department of Radiation Oncology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, China 

View references (59)

Abstract

Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate thebiomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curative effect and survival rate. Here, we reviewed the potentialbiomarkers of esophageal cancer in three aspects: Immunohistochemical markers, blood-based markers, miRNA markers and Gene expression profiling. All these biomarkers provided promising therapeutic targets for the diagnosis, treatment, and prognosis of esophageal cancer. © 2016, Tan et al.

ISSN: 21931801Source Type: Journal Original language: English

DOI: 10.1186/s40064-016-2119-3Document Type: Review

Publisher: SpringerOpen

References (59)

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  1

  Akamatsu, M., Matsumoto, T., Oka, K., Yamasaki, S., Sonoue, H., Kajiyama, Y., Tsurumaru, M., (...), Sasai, K.

  c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma
  (2003) International Journal of Radiation Oncology Biology Physics, 57 (5), pp. 1323-1327. Cited 58 times.
  doi: 10.1016/S0360-3016(03)00782-X
  

  • View at Publisher
• 
  2

  Anderson, K.S., LaBaer, J.

  The sentinel within: Exploiting the immune system for cancer biomarkers
  (2005) Journal of Proteome Research, 4 (4), pp. 1123-1133. Cited 158 times.
  doi: 10.1021/pr0500814
  

  • View at Publisher
• 
  3

  Bagaria, B., Sood, S., Sharma, R., Lalwani, S.

  Comparative study of CEA and CA19-9 in esophageal, gastric and colon cancers individually and in combination (ROC curve analysis)
  (2013) Cancer Biology and Medicine, 10 (3), pp. 148-157. Cited 13 times.
  doi: 10.7497/j.issn.2095-3941.2013.03.005
  

  • View at Publisher
• 
  4

  Berry, M.F.

  Esophageal cancer: Staging system and guidelines for staging and treatment
  (2014) Journal of Thoracic Disease, 6 (SUPPL.3), pp. S289-S297. Cited 13 times.
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037413/pdf/jtd-06-S3-S289.pdf
  doi: 10.3978/j.issn.2072-1439.2014.03.11
  

  • View at Publisher
• 
  5

  Bird-Lieberman, E.L., Dunn, J.M., Coleman, H.G., Lao-Sirieix, P., Oukrif, D., Moore, C.E.
  Population-based study reveals new risk-stratification biomarker panel for Barrett’s esophagus
  (2012) Gastroenterology, 143 (4), pp. 920-927.
  

  •  
• 
  6

  Cerfolio, R.J., Bryant, A.S., Ohja, B., Bartolucci, A.A., Eloubeidi, M.A.

  The accuracy of endoscopic ultrasonography with fine-needle aspiration, integrated positron emission tomography with computed tomography, and computed tomography in restaging patients with esophageal cancer after neoadjuvant chemoradiotherapy
  (2005) Journal of Thoracic and Cardiovascular Surgery, 129 (6), pp. 1232-1241. Cited 147 times.
  doi: 10.1016/j.jtcvs.2004.12.042
  

  • View at Publisher
• 
  7

  Chan, D.S.Y., Twine, C.P., Lewis, W.G.

  Systematic Review and Meta-analysis of the Influence of HER2 Expression and Amplification in Operable Oesophageal Cancer
  (2012) Journal of Gastrointestinal Surgery, 16 (10), pp. 1821-1829. Cited 24 times.
  doi: 10.1007/s11605-012-1979-2
  

  • View at Publisher
• 
  8

  Dimaio, M.A., Kwok, S., Montgomery, K.D., Lowe, A.W., Pai, R.K.

  Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: A combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping
  (2012) Human Pathology, 43 (11), pp. 1799-1807. Cited 13 times.
  doi: 10.1016/j.humpath.2012.03.019
  

  • View at Publisher
• 
  9

  Dong, J., Zeng, B.-H., Xu, L.-H., Wang, J.-Y., Li, M.-Z., Zeng, M.-S., Liu, W.-L.

  Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma
  (2010) Journal of Translational Medicine, 8, art. no. 81. Cited 18 times.
  http://www.translational-medicine.com/content/8/1/81
  doi: 10.1186/1479-5876-8-81
  

  • View at Publisher
• 
  10

  Dreilich, M., Wanders, A., Brattström, D., Bergström, S., Hesselius, P., Wagenius, G., Bergqvist, M.

  HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival
  (2006) Diseases of the Esophagus, 19 (4), pp. 224-231. Cited 35 times.
  doi: 10.1111/j.1442-2050.2006.00570.x
  

  • View at Publisher
• 
  11

  Duong, C., Greenawalt, D.M., Kowalczyk, A., Ciavarella, M.L., Raskutti, G., Murray, W.K., Phillips, W.A., (...), Thomas, R.J.S.

  Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer
  (2007) Annals of Surgical Oncology, 14 (12), pp. 3602-3609. Cited 35 times.
  doi: 10.1245/s10434-007-9550-1
  

  • View at Publisher
• 
  12

  Enzinger, P.C., Mayer, R.J.

  Esophageal Cancer
  (2003) New England Journal of Medicine, 349 (23), pp. 2241-2252. Cited 1465 times.
  doi: 10.1056/NEJMra035010
  

  • View at Publisher
• 
  13

  Finn, O.J.

  Immune response as a biomarker for cancer detection and a lot more
  (2005) New England Journal of Medicine, 353 (12), pp. 1288-1290. Cited 63 times.
  http://content.nejm.org/cgi/reprint/353/12/1288.pdf
  doi: 10.1056/NEJMe058157
  

  • View at Publisher
• 
  14

  Fitzgerald, R.C., Di Pietro, M., Ragunath, K., Ang, Y., Kang, J.-Y., Watson, P., Trudgill, N., (...), De Caestecker, J.

  British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus
  (2014) Gut, 63 (1), pp. 7-42. Cited 171 times.
  http://gut.bmj.com/content/63/1/7.full.pdf
  doi: 10.1136/gutjnl-2013-305372
  

  • View at Publisher
• 
  15

  Glickman, J.N., Yang, A., Shahsafaei, A., McKeon, F., Odze, R.D.

  Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
  (2001) Human Pathology, 32 (11), pp. 1157-1165. Cited 91 times.
  doi: 10.1053/hupa.2001.28951
  

  • View at Publisher
• 
  16

  Hiyoshi, Y., Kamohara, H., Karashima, R., Sato, N., Imamura, Y., Nagai, Y., Yoshida, N., (...), Baba, H.

  MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma
  (2009) Clinical Cancer Research, 15 (6), pp. 1915-1922. Cited 161 times.
  http://clincancerres.aacrjournals.org/cgi/reprint/15/6/1915
  doi: 10.1158/1078-0432.CCR-08-2545
  

  • View at Publisher
• 
  17

  Huang, Y.-W., Liu, J.C., Deatherage, D.E., Luo, J., Mutch, D.G., Goodfellow, P.J., Miller, D.S., (...), Huang, T.H.-M.

  Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer
  (2009) Cancer Research, 69 (23), pp. 9038-9046. Cited 161 times.
  http://cancerres.aacrjournals.org/cgi/reprint/69/23/9038
  doi: 10.1158/0008-5472.CAN-09-1499
  

  • View at Publisher
• 
  18

  Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D.

  Global cancer statistics
  (2011) CA Cancer Journal for Clinicians, 61 (2), pp. 69-90. Cited 16225 times.
  doi: 10.3322/caac.20107
  

  • View at Publisher
• 
  19

  Kan, T., Sato, F., Ito, T., Matsumura, N., David, S., Cheng, Y., Agarwal, R., (...), Meltzer, S.J.

  The miR-106b-25 Polycistron, Activated by Genomic Amplification, Functions as an Oncogene by Suppressing p21 and Bim
  (2009) Gastroenterology, 136 (5), pp. 1689-1700. Cited 158 times.
  doi: 10.1053/j.gastro.2009.02.002
  

  • View at Publisher
• 
  20

  Kang, M., Li, Y., Liu, W., Wang, R., Tang, A., Hao, H., Liu, Z., (...), Ou, H.

  miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression
  (2013) International Journal of Molecular Medicine, 32 (1), pp. 51-58. Cited 26 times.
  http://www.spandidos-publications.com/serveFile/ijmm_32_1_51_PDF.pdf?type=article&article_id=ijmm_32_1_51&item=PDF
  doi: 10.3892/ijmm.2013.1384
  

  • View at Publisher
• 
  21

  Kaye, P.V., Haider, S.A., Ilyas, M., James, P.D., Soomro, I., Faisal, W., Catton, J., (...), Ragunath, K.

  Barrett's dysplasia and the Vienna classification: Reproducibility, prediction of progression and impact of consensus reporting and p53 immunohistochemistry
  (2009) Histopathology, 54 (6), pp. 699-712. Cited 61 times.
  doi: 10.1111/j.1365-2559.2009.03288.x
  

  • View at Publisher
• 
  22

  Kilic, A., Schuchert, M.J., Luketich, J.D., Landreneau, R.J., Lokshin, A.E., Bigbee, W.L., El-Hefnawy, T.

  Use of novel autoantibody and cancer-related protein arrays for the detection of esophageal adenocarcinoma in serum
  (2008) Journal of Thoracic and Cardiovascular Surgery, 136 (1), pp. 199-204. Cited 13 times.
  doi: 10.1016/j.jtcvs.2008.01.012
  

  • View at Publisher
• 
  23

  Kumar, A., Chatopadhyay, T., Raziuddin, M., Ralhan, R.

  Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray
  (2007) International Journal of Cancer, 120 (2), pp. 230-242. Cited 27 times.
  doi: 10.1002/ijc.22246
  

  • View at Publisher
• 
  24

  Lesnikova, I., Lidang, M., Hamilton-Dutoit, S., Koch, J.

  HER2/neu (c-erbB-2) gene amplification and protein expression are rare in uterine cervical neoplasia: A tissue microarray study of 814 archival specimens
  (2009) APMIS, 117 (10), pp. 737-745. Cited 9 times.
  doi: 10.1111/j.1600-0463.2009.02531.x
  

  • View at Publisher
• 
  25

  Luthra, R., Singh, R.R., Luthra, M.G., Li, Y.X., Hannah, C., Romans, A.M., Barkoh, B.A., (...), Albarracin, C.T.

  MicroRNA-196a targets annexin A1: A microRNA-mediated mechanism of annexin A1 downregulation in cancers
  (2008) Oncogene, 27 (52), pp. 6667-6678. Cited 144 times.
  doi: 10.1038/onc.2008.256
  

  • View at Publisher
• 
  26

  Mathé, E.A., Giang, H.N., Bowman, E.D., Zhao, Y., Budhu, A., Schetter, A.J., Braun, R., (...), Harris, C.C.

  MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival
  (2009) Clinical Cancer Research, 15 (19), pp. 6192-6200. Cited 222 times.
  http://clincancerres.aacrjournals.org/content/15/19/6192.full.pdf
  doi: 10.1158/1078-0432.CCR-09-1467
  

  • View at Publisher
• 
  27

  Matsushima, K., Isomoto, H., Yamaguchi, N., Inoue, N., Machida, H., Nakayama, T., Hayashi, T., (...), Nakao, K.

  MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
  (2011) Journal of Translational Medicine, 9, art. no. 30. Cited 52 times.
  http://www.translational-medicine.com/content/9/1/30
  doi: 10.1186/1479-5876-9-30
  

  • View at Publisher
• 
  28

  Motoori, M., Takemasa, I., Yamasaki, M., Komori, T., Takeno, A., Miyata, H., Takiguchi, S., (...), Doki, Y.

  Prediction of the response to chemotherapy in advanced esophageal cancer by gene expression profiling of biopsy samples
  (2010) International Journal of Oncology, 37 (5), pp. 1113-1120. Cited 12 times.
  http://www.spandidos-publications.com/serveFile/ijo_37_5_1113_PDF.pdf?type=article&article_id=ijo_37_5_1113&item=PDF
  doi: 10.3892/ijo-00000763
  

  • View at Publisher
• 
  29

  Ohta, M., Mimori, K., Fukuyoshi, Y., Kita, Y., Motoyama, K., Yamashita, K., Ishii, H., (...), Mori, M.

  Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer
  (2008) British Journal of Cancer, 98 (2), pp. 410-417. Cited 18 times.
  doi: 10.1038/sj.bjc.6604124
  

  • View at Publisher
• 
  30

  Pacha, A., Rygiel, A.M., Westra, W., Dijkgraaf, M.G., Rosmolen, W., Visser, M.
  Su1181 A diagnostic DNA fish biomarker assay identifies HGD or EAC in Barrett esophagus
  (2012) Elsevier Gastroenterol, 142 (5), p. 445.
  

  •  
• 
  31

  Penault-Llorca, F., Bilous, M., Dowsett, M., Hanna, W., Osamura, R.Y., Rüschoff, J., Van De Vijver, M.

  Emerging technologies for assessing HER2 amplification
  (2009) American Journal of Clinical Pathology, 132 (4), pp. 539-548. Cited 82 times.
  http://ajcp.ascpjournals.org/content/132/4/539.full.pdf
  doi: 10.1309/AJCPV2I0HGPMGBSQ
  

  • View at Publisher
• 
  32

  Quackenbush, J.

  Microarray analysis and tumor classification
  (2006) New England Journal of Medicine, 354 (23), pp. 2463-2472. Cited 306 times.
  http://content.nejm.org/cgi/reprint/354/23/2463.pdf
  doi: 10.1056/NEJMra042342
  

  • View at Publisher
• 
  33

  Rice, T.W., Zuccaro Jr., G., Adelstein, D.J., Rybicki, L.A., Blackstone, E.H., Goldblum, J.R.

  Esophageal carcinoma: Depth of tumor invasion is predictive of regional lymph node status
  (1998) Annals of Thoracic Surgery, 65 (3), pp. 787-792. Cited 238 times.
  doi: 10.1016/S0003-4975(97)01387-8
  

  • View at Publisher
• 
  34

  Rice, T.W., Rusch, V.W., Apperson-Hansen, C., Allen, M.S., Chen, L.-Q., Hunter, J.G., Kesler, K.A., (...), Blackstone, E.H.

  Worldwide esophageal cancer collaboration
  (2009) Diseases of the Esophagus, 22 (1), pp. 1-8. Cited 172 times.
  doi: 10.1111/j.1442-2050.2008.00901.x
  

  • View at Publisher
• 
  35

  Rygiel, A.M., Van Baal, J.W.P.M., Milano, F., Wang, K.K., Ten Kate, F.J., Fockens, P., Rosmolen, W.D., (...), Krishnadath, K.K.

  Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population
  (2007) Cancer, 109 (10), pp. 1980-1988. Cited 25 times.
  doi: 10.1002/cncr.22643
  

  • View at Publisher
• 
  36

  Salehi, M., Moradi-Lakeh, M., Salehi, M.H., Nojomi, M., Kolahdooz, F.

  Meat, fish, and esophageal cancer risk: A systematic review and dose-response meta-analysis
  (2013) Nutrition Reviews, 71 (5), pp. 257-267. Cited 37 times.
  doi: 10.1111/nure.12028
  

  • View at Publisher
• 
  37

  Schauer, M., Janssen, K.-P., Rimkus, C., Raggi, M., Feith, M., Friess, H., Theisen, J.

  Microarray-based response prediction in esophageal adenocarcinoma
  (2010) Clinical Cancer Research, 16 (1), pp. 330-337. Cited 33 times.
  http://clincancerres.aacrjournals.org/content/16/1/330.full.pdf+html
  doi: 10.1158/1078-0432.CCR-09-1673
  

  • View at Publisher
• 
  38

  Shimada, H., Nakashima, K., Ochiai, T., Nabeya, Y., Takiguchi, M., Nomura, F., Hiwasa, T.

  Serological identification of tumor antigens of esophageal squamous cell carcinoma.
  (2005) International journal of oncology, 26 (1), pp. 77-86. Cited 29 times.
  
• 
  39

  Sikkema, M., Kerkhof, M., Steyerberg, E.W., Kusters, J.G., Van Strien, P.M.H., Looman, C.W.N., Van Dekken, H., (...), Kuipers, E.J.

  Aneuploidy and overexpression of Ki67 and p53 as markers for neoplastic progression in Barrett's esophagus: A case-control study
  (2009) American Journal of Gastroenterology, 104 (11), pp. 2673-2680. Cited 51 times.
  doi: 10.1038/ajg.2009.437
  

  • View at Publisher
• 
  40

  Skacel, M., Petras, R.E., Rybicki, L.A., Gramlich, T.L., Richter, J.E., Falk, G.W., Goldblum, J.R.

  p53 expression in low grade dysplasia in Barrett's esophagus: Correlation with interobserver agreement and disease progression
  (2002) American Journal of Gastroenterology, 97 (10), pp. 2508-2513. Cited 74 times.
  doi: 10.1016/S0002-9270(02)04390-3
  

  • View at Publisher
• 
  41

  Smith, C.M., Watson, D.I., Leong, M.P., Mayne, G.C., Michael, M.Z., Wijnhoven, B.P., Hussey, D.J.

  Mir-200 family expression is downregulated upon neoplastic progression of barrett's esophagus
  (2011) World Journal of Gastroenterology, 17 (8), pp. 1036-1044. Cited 26 times.
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057147/pdf/WJG-17-1036.pdf
  doi: 10.3748/wjg.v17.i8.1036
  

  • View at Publisher
• 
  42

  Spector, N.L., Blackwell, K.L.

  Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
  (2009) Journal of Clinical Oncology, 27 (34), pp. 5838-5847. Cited 231 times.
  http://jco.ascopubs.org/cgi/reprint/27/34/5838
  doi: 10.1200/JCO.2009.22.1507
  

  • View at Publisher
• 
  43

  Sudo, T., Mimori, K., Nagahara, H., Utsunomiya, T., Fujita, H., Tanaka, Y., Shirouzu, K., (...), Mori, M.

  Identification of EGFR mutations in esophageal cancer
  (2007) European Journal of Surgical Oncology, 33 (1), pp. 44-48. Cited 30 times.
  doi: 10.1016/j.ejso.2006.10.034
  

  • View at Publisher
• 
  44

  Tan, E.M., Zhang, J.

  Autoantibodies to tumor-associated antigens: Reporters from the immune system
  (2008) Immunological Reviews, 222 (1), pp. 328-340. Cited 95 times.
  doi: 10.1111/j.1600-065X.2008.00611.x
  

  • View at Publisher
• 
  45

  Tan, H.T., Low, J., Lim, S.G., Chung, M.C.M.

  Serum autoantibodies as biomarkers for early cancer detection
  (2009) FEBS Journal, 276 (23), pp. 6880-6904. Cited 135 times.
  doi: 10.1111/j.1742-4658.2009.07396.x
  

  • View at Publisher
• 
  46

  Thompson, S.K., Ruszkiewicz, A.R., Jamieson, G.G., Esterman, A., Watson, D.I., Wijnhoven, B.P.L., Lamb, P.J., (...), Devitt, P.G.

  Improving the accuracy of TNM staging in esophageal cancer: A pathological review of resected specimens
  (2008) Annals of Surgical Oncology, 15 (12), pp. 3447-3458. Cited 49 times.
  doi: 10.1245/s10434-008-0155-0
  

  • View at Publisher
• 
  47

  Uemura, N., Kondo, T.
  Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer
  (2014) World J Gastrointest Pathophysiol, 5 (3), pp. 322-334.
  

  •  
• 
  48

  Vervoort, S.J., Van Boxtel, R., Coffer, P.J.

  The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: Friend or foe¿
  (2013) Oncogene, 32 (29), pp. 3397-3409. Cited 38 times.
  doi: 10.1038/onc.2012.506
  

  • View at Publisher
• 
  49

  Wang, K.L., Wu, T.-T., In, S.C., Wang, H., Reseetkova, E., Correa, A.M., Hofstetter, W.L., (...), Albarracin, C.T.

  Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: Association with poor outcome
  (2007) Cancer, 109 (4), pp. 658-667. Cited 119 times.
  doi: 10.1002/cncr.22445
  

  • View at Publisher
• 
  50

  Wang, Q., Zhu, H., Xiao, Z., Zhang, W., Liu, X., Zhang, X., He, J., (...), Xu, N.

  Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma
  (2013) World Journal of Surgical Oncology, 11, art. no. 278. Cited 7 times.
  http://www.wjso.com/content/11/1/278
  doi: 10.1186/1477-7819-11-278
  

  • View at Publisher
• 
  51

  Weston, A.P., Banerjee, S.K., Sharma, P., Tran, T.M., Richards, R., Cherian, R.

  p53 protein overexpression in low grade dysplasia (LGD) in Barrett's esophagus: Immunohistochemical marker predictive of progression
  (2001) American Journal of Gastroenterology, 96 (5), pp. 1355-1362. Cited 159 times.
  doi: 10.1016/S0002-9270(01)02414-5
  

  • View at Publisher
• 
  52

  Xu, Y.-W., Peng, Y.-H., Chen, B., Wu, Z.-Y., Wu, J.-Y., Shen, J.-H., Zheng, C.-P., (...), Xu, L.-Y.

  Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma
  (2014) American Journal of Gastroenterology, 109 (1), pp. 36-45. Cited 15 times.
  http://www.nature.com/ajg/archive/index.html
  doi: 10.1038/ajg.2013.384
  

  • View at Publisher
• 
  53

  Zaenker, P., Ziman, M.R.

  Serologic autoantibodies as diagnostic cancer biomarkers - A review
  (2013) Cancer Epidemiology Biomarkers and Prevention, 22 (12), pp. 2161-2181. Cited 23 times.
  http://cebp.aacrjournals.org/content/22/12/2161.full.pdf+html
  doi: 10.1158/1055-9965.EPI-13-0621
  

  • View at Publisher
• 
  54

  Zali, H., Ahmadi, G., Bakhshandeh, R., Rezaei-Tavirani, M.
  Proteomic analysis of gene expression during human esophagus cancer
  (2011) J Paramed Sci, 2, pp. 37-44.
  

  •  
• 
  55

  Zhang, H., Li, M., Han, Y., Hong, L., Gong, T., Sun, L., Zheng, X.

  Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma
  (2010) Digestive Diseases and Sciences, 55 (9), pp. 2545-2551. Cited 77 times.
  doi: 10.1007/s10620-009-1051-6
  

  • View at Publisher
• 
  56

  Zhang, J., Xv, Z., Wu, X., Li, K.

  Potential Diagnostic Value of Serum p53 Antibody for Detecting Esophageal Cancer: A Meta-Analysis
  (2012) PLoS ONE, 7 (12), art. no. e52896. Cited 3 times.
  http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0052896&representation=PDF
  doi: 10.1371/journal.pone.0052896
  

  • View at Publisher
• 
  57

  Zhang, H.-F., Xu, L.-Y., Li, E.-M.

  A family of pleiotropically acting micrornas in cancer progression, mir-200: Potential cancer therapeutic targets
  (2014) Current Pharmaceutical Design, 20 (11), pp. 1896-1903. Cited 9 times.
  http://www.ingentaconnect.com/content/ben/cpd
  doi: 10.2174/13816128113199990519
  

  • View at Publisher
• 
  58

  Zhang, H.-F., Zhang, K., Liao, L.-D., Li, L.-Y., Du, Z.-P., Wu, B.-L., Wu, J.-Y., (...), Li, E.-M.

  miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2
  (2014) Carcinogenesis, 35 (2), art. no. bgt320, pp. 292-301. Cited 13 times.
  doi: 10.1093/carcin/bgt320
  

  • View at Publisher
• 
  59

  Zuguchi, M., Miki, Y., Onodera, Y., Fujishima, F., Takeyama, D., Okamoto, H., Miyata, G., (...), Sasano, H.

  Estrogen receptor α and β in esophageal squamous cell carcinoma
  (2012) Cancer Science, 103 (7), pp. 1348-1355. Cited 7 times.
  doi: 10.1111/j.1349-7006.2012.02288.x
  

  • View at Publisher

  Cai, J.; Department of Radiation Oncology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, China; email:cj7227@sina.com
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