Progress of medicinal plant-derived active substances for Alzheimer's disease

Drugs of the Future

Volume 40, Issue 7, 1 July 2015, Pages 443-466

Hao, G., 

Zhang, Q. 

 

School of Pharmaceutical Sciences, Shandong University, Jinan, China 

View references (333)

Abstract

In traditional medicine, a variety of plants have shown favorable effects in the therapy of diseases associated with cognitive dysfunction and memory loss. Lately, a large number of phytoconstituents have been studied for their potential in the treatment of Alzheimer's disease, including compounds that inhibit acetylcholinesterase, demonstrate antioxidant activity, have anti-inflammatory effects, inhibit beta-amyloid accumulation or tau aggregation, and improve mitochondrial dysfunction. This article discusses the current situation of basic research and clinical trials on substances derived from medicinal plants to provide basic data for further research and new drug development. Copyright © 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Medicinal plants; Multiple targets

Indexed keywords

EMTREE drug terms: alkaloid derivative; cholinesterase; cholinesterase inhibitor; curcumin; Ginkgo biloba extract; glycoside; herbaceous agent; huperzine A; natural product; nic 5 15; nootropic agent; plant extract; polyphenol derivative; polysaccharide; resveratrol; Salvia officinalis extract; saponin derivative; sterol derivative; stilbene derivative; terpenoid derivative; unclassified drug; withanolide; xanthone derivative

EMTREE medical terms: Ajuga; Ajuga bracteosa; Alzheimer disease; antioxidant activity; blueberry; Caragana; Caragana chamlague; cholinergic stimulation; cholinergic system; cholinesterase inhibition; cinnamon; clinical trial (topic); Curcuma longa; diffuse Lewy body disease; Electrophorus; Ganoderma; Ganoderma applanatum; Ganoderma atrum; Ganoderma lucidum; gentian; Gentiana campestris; Ginkgo biloba; ginseng; grape; human; Huperzia; Huperzia serrata; Lentinula edodes; Lycium barbarum; Magnolia; medicinal mushroom; medicinal plant; Melissa officinalis; Micromeria cilicica; nonhuman; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 4 clinical trial (topic); randomized controlled trial (topic); Review; Salvia; Salvia lavandulaefolia; tea; traditional medicine; Trametes versicolor

Chemicals and CAS Registry Numbers: cholinesterase, 9001-08-5; curcumin, 458-37-7; huperzine A, 102518-79-6, 92138-20-0; resveratrol, 501-36-0; withanolide, 40326-62-3

Drug tradename: nic 5 15.

ISSN: 03778282 CODEN: DRFUDSource Type: Journal Original language: English

DOI: 10.1358/dof.2015.040.07.2374837Document Type: Review

Publisher: Prous Science

References (333)

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  Zhang, Q.; School of Pharmaceutical Sciences, Shandong University, China
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