The importance of botanical treatments in traditional societies and challenges in developing countries

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Epilepsy and Behavior

Volume 52, November 01, 2015, Pages 297-307

The importance of botanical treatments in traditional societies and challenges in developing countries  (Review)

Kakooza-Mwesige, A.^ab 

 

^a  Department of Paediatrics and Child Health, Makerere University College of Health Sciences and Mulago Hospital, Kampala, Uganda
^b  Astrid Lindgren Children's Hospital, Department of Women's and Children's Health, Neuropediatric Research Unit, Karolinska Institutet, Stockholm, Sweden 

View references (141)

Abstract

Epilepsy is one of the most common neurological conditions worldwide, with many affected persons found in Asia, Latin America, and sub-Saharan Africa. Relatedly, the large majority found in these regions does not receive the appropriate therapy with antiepileptic drugs (AEDs), stemming from various reasons among which are lack of access to AEDs, social stigma, and negative cultural attitudes. The presence of epilepsy resistant to the available AEDs coupled with the frequent AED side effects has further fueled the widespread and growing use of botanicals as alternative therapy in several traditional societies in these developing countries since people with epilepsy (PWE) consider them as safe and effective. There have, however, been few botanicals that have been examined for their pharmacological activities related to traditional uses, and there is hardly any conclusive evidence regarding their efficacy in humans or knowledge about the exact mechanism(s) of action. This review discusses some botanical treatments that have been used for epilepsy in developing countries and the challenges faced. This article is part of a Special Issue entitled "Botanicals for Epilepsy". © 2015 Elsevier Inc.

Author keywords

Botanicals; Challenges; Efficacy; Epilepsy; Safety; Traditional societies

Indexed keywords

EMTREE drug terms: benzodiazepine receptor; br 16a; cannabidiol; carbamazepine; herbaceous agent; phenobarbital; phenytoin

EMTREE medical terms: Africa south of the Sahara; anticonvulsant activity; Asia; Ayurveda; developing country; drug efficacy; drug safety; electric shock; epilepsy; geographic distribution; human; Korean medicine; medicinalplant; nonhuman; phytochemistry; plant leaf; plant root; Review; sedation; South and Central America; unspecified side effect

Chemicals and CAS Registry Numbers: cannabidiol, 13956-29-1; carbamazepine, 298-46-4, 8047-84-5; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; phenytoin, 57-41-0, 630-93-3

Drug tradename: mentat.

ISSN: 15255050 CODEN: EBPEASource Type: Journal Original language: English

DOI: 10.1016/j.yebeh.2015.06.017Document Type: Review

Publisher: Academic Press Inc.

References (141)

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• 
  1

  Ngugi, A.K., Bottomley, C., Kleinschmidt, I., Sander, J.W., Newton, C.R.

  Estimation of the burden of active and life-time epilepsy: A meta-analytic approach
  (2010) Epilepsia, 51 (5), pp. 883-890. Cited 196 times.
  http://www3.interscience.wiley.com/cgi-bin/fulltext/123235434/PDFSTART
  doi: 10.1111/j.1528-1167.2009.02481.x
  

  • View at Publisher
• 
  2

  Gregory, D., Johnston, R., Pratt, G., Watts, M., Whatmore, S.
  (2009) Dictionary of human geography. Cited 139 times.
  Wiley-Blackwell
  

  •  
• 
  3

  Mbuba, C.K., Ngugi, A.K., Newton, C.R., Carter, J.A.

  The epilepsy treatment gap in developing countries: A systematic review of the magnitude, causes, and intervention strategies
  (2008) Epilepsia, 49 (9), pp. 1491-1503. Cited 96 times.
  doi: 10.1111/j.1528-1167.2008.01693.x
  

  • View at Publisher
• 
  4

  Winkler, A.S., Mayer, M., Ombay, M., Mathias, B., Schmutzhard, E., Jilek-Aall, L.

  Attitudes towards African traditional medicine and christian spiritual healing regarding treatment of epilepsy in a rural community of northern Tanzania
  (2010) African Journal of Traditional, Complementary and Alternative Medicines, 7 (2), pp. 162-170. Cited 14 times.
  http://www.bioline.org.br/pdf?tc10024
  

  • View at Publisher
• 
  5

  Newton, C.R., Garcia, H.H.

  Epilepsy in poor regions of the world
  (2012) The Lancet, 380 (9848), pp. 1193-1201. Cited 74 times.
  doi: 10.1016/S0140-6736(12)61381-6
  

  • View at Publisher
• 
  6

  Meinardi, H., Scott, R.A., Reis, R., Sander, J.W.A.S.

  The treatment gap in epilepsy: The current situation and ways forward
  (2001) Epilepsia, 42 (1), pp. 136-149. Cited 194 times.
  doi: 10.1046/j.1528-1157.2001.32800.x
  

  • View at Publisher
• 
  7

  Sørensen, A.T., Kokaia, M.

  Novel approaches to epilepsy treatment
  (2013) Epilepsia, 54 (1), pp. 1-10. Cited 25 times.
  doi: 10.1111/epi.12000
  

  • View at Publisher
• 
  8

  Meyer, A.-C., Dua, T., Ma, J., Saxena, S., Birbeck, G.

  Global disparities in the epilepsy treatment gap: A systematic review
  (2010) Bulletin of the World Health Organization, 88 (4), pp. 260-266. Cited 112 times.
  http://www.who.int/entity/bulletin/volumes/88/4/09-064147.pdf
  doi: 10.2471/BLT.09.064147
  

  • View at Publisher
• 
  9

  Zhu, H.-L., Wan, J.-B., Wang, Y.-T., Li, B.-C., Xiang, C., He, J., Li, P.

  Medicinal compounds with antiepileptic/anticonvulsant activities
  (2014) Epilepsia, 55 (1), pp. 3-16. Cited 9 times.
  doi: 10.1111/epi.12463
  

  • View at Publisher
• 
  10

  Samuels, N., Finkelstein, Y., Singer, S.R., Oberbaum, M.

  Herbal medicine and epilepsy: Proconvulsive effects and interactions with antiepileptic drugs
  (2008) Epilepsia, 49 (3), pp. 373-380. Cited 39 times.
  doi: 10.1111/j.1528-1167.2007.01379.x
  

  • View at Publisher
• 
  11

  (2013) WHO traditional medicine strategy: 2014-2023. Cited 67 times.
  WHO, Geneva
  

  •  
• 
  12

  Warude, D., Patwardhan, B.

  Botanicals: Quality and regulatory issues
  (2005) Journal of Scientific and Industrial Research, 64 (2), pp. 83-92. Cited 15 times.
  
• 
  13

  Oniyangi, O., Cohall, D.H.

  Phytomedicines (medicines derived from plants) for sickle cell disease.
  (2013) Cochrane database of systematic reviews (Online), 1, p. CD004448. Cited 3 times.
  
• 
  14

  Kelly, K.
  (2009) History of medicine, facts on file
  An imprint of Infobase Publishing, New York NY 10001
  

  •  
• 
  15

  Wiart, C.
  (2006) Ethnopharmacology of medicinal plants, pp. 1-50. Cited 45 times.
  Humana Press, New Jersey
  

  •  
• 
  16

  Langlois, S.
  Traditions: social
  (2001) International encyclopedia of the social & behavioral sciences, pp. 15829-15833.
  Pergamon, Oxford, N.J. Smelser, P.B. Baltes (Eds.)
  

  •  
• 
  17

  Idu, M.

  Current trends in ethnobotany
  (2009) Tropical Journal of Pharmaceutical Research, 8 (4), pp. 295-297. Cited 4 times.
  http://www.tjpr.org/vol8_no4/2009_8_4_1_Editorial.pdf
  
• 
  18

  Barnes, P.M., Bloom, B.
  (2008) Complementary and alternative medicine use among adults and children: United States, 2007. Cited 459 times.
  National Center for Health Statistics, Hyattsville, MD, (National health statistics reports, No. 12)
  

  •  
• 
  19

  Balint, G.A.

  Artemisinin and its derivatives: An important new class of antimalarial agents
  (2001) Pharmacology and Therapeutics, 90 (2-3), pp. 261-265. Cited 114 times.
  doi: 10.1016/S0163-7258(01)00140-1
  

  • View at Publisher
• 
  20

  Ikeda, Y., Fujii, Y., Nakaya, I., Yamazaki, M.

  Quantitative HPLC analysis of cardiac glycosides in Digitalis purpurea leaves
  (1995) Journal of Natural Products (Lloydia), 58 (6), pp. 897-901. Cited 14 times.
  doi: 10.1021/np50120a012
  

  • View at Publisher
• 
  21

  Witters, L.A.

  The blooming of the French lilac
  (2001) Journal of Clinical Investigation, 108 (8), pp. 1105-1107. Cited 171 times.
  doi: 10.1172/JCI200114178
  

  • View at Publisher
• 
  22

  Gulla, J., Singer, A.J.

  Use of alternative therapies among emergency department patients
  (2000) Annals of Emergency Medicine, 35 (3), pp. 226-228. Cited 56 times.
  

  • View at Publisher
• 
  23

  Easterford, K., Clough, P., Comish, S., Lawton, L., Duncan, S.

  The use of complementary medicines and alternative practitioners in a cohort of patients with epilepsy
  (2005) Epilepsy and Behavior, 6 (1), pp. 59-62. Cited 32 times.
  doi: 10.1016/j.yebeh.2004.10.007
  

  • View at Publisher
• 
  24

  Okeke, T.A., Okafor, H.U., Uzochukwu, B.S.C.

  Traditional healers in Nigeria: Perception of cause, treatment and referral practices for severe malaria
  (2006) Journal of Biosocial Science, 38 (4), pp. 491-500. Cited 25 times.
  doi: 10.1017/S002193200502660X
  

  • View at Publisher
• 
  25

  Danesi, M.A., Adetunji, J.B.

  Use of alternative medicine by patients with epilepsy: A survey of 265 epileptic patients in a developing country
  (1994) Epilepsia, 35 (2), pp. 344-351. Cited 73 times.
  

  • View at Publisher
• 
  26

  Oshikoya, K.A., Senbanjo, I.O., Njokanma, O.F., Soipe, A.

  Use of complementary and alternative medicines for children with chronic health conditions in Lagos, Nigeria
  (2008) BMC Complementary and Alternative Medicine, 8, art. no. 66. Cited 33 times.
  doi: 10.1186/1472-6882-8-66
  

  • View at Publisher
• 
  27

  Hostettmann, K., Marston, A., Ndjoko, K., Wolfender, J.-L.

  The potential of African plants as a source of drugs
  (2000) Current Organic Chemistry, 4 (10), pp. 973-1010. Cited 107 times.
  

  • View at Publisher
• 
  28

  Woldeamanuel, Y.W., Girma, B.

  Contributing Towards the Betterment of Translational Epilepsy Research in Africa: Needs, Challenges, Resources, and Opportunities
  (2014) Current Neurology and Neuroscience Reports, 14 (8).
  doi: 10.1007/s11910-014-0470-8
  

  • View at Publisher
• 
  29

  Brendler, T., Eloff, J.N., Gurib-Fakim, A., Phillips, D.
  (2010) African herbal pharmacopoeia. Cited 22 times.
  Graphic, Mauritius, (Eds.)
  

  •  
• 
  30

  Oyebola, D.D.O.

  Cow's urine concoction: Its chemical composition, pharmacological actions and mode of lethality
  (1983) African Journal of Medicine and Medical Sciences, 12 (1), pp. 57-63. Cited 15 times.
  
• 
  31

  Salahdeen, H.M., Fagbohun, T.R.

  Effects of cow urine concoction and nicotine on the nerve-muscle preparation in common African toad Bufo regularis
  (2005) Biomedical Research, 16 (3), pp. 205-211.
  
• 
  32

  Adekile, A.D., Odebiyi, O.O., Ojewole, J.A.O.

  Pharmacological studies on a Nigerian herbal preparation: II. Anticonvulsant evaluation of cow's urine concoction (CUC) and its individual components
  (1983) Journal of Tropical Pediatrics, 29 (6), pp. 299-302. Cited 7 times.
  

  • View at Publisher
• 
  33

  Jarrett, O.O., Fatunde, O.J., Osinusi, K., Lagunju, I.A.
  Pre-hospital management of febrile seizures in children seen at the University College Hospital, Ibadan, Nigeria
  (2012) Ann Ib Postgrad Med, 10, pp. 6-10. Cited 2 times.
  

  •  
• 
  34

  Holmes, G.L.

  Animal model studies application to human patients
  (2007) Neurology, 69 (24 SUPPL. 3), pp. S28-S32. Cited 27 times.
  doi: 10.1212/01.wnl.0000302369.24230.c6
  

  • View at Publisher
• 
  35

  Campbell, S.

  Traditional medicine in The Gambia.
  (1997) Complementary therapies in nursing & midwifery, 3 (4), pp. 103-105. Cited 3 times.
  

  • View at Publisher
• 
  36

  Romeiras, M.M., Duarte, M.C., Indjai, B., Catarino, L.
  Medicinal plants used to treat neurological disorders in West Africa: a case study with Guinea-Bissau Flora
  (2012) Am J Plant Sci, 3, pp. 1028-1036. Cited 5 times.
  

  •  
• 
  37

  Gelfand, M., Drummond, R.B., Mavi, S., Ndemera, B.
  (1985) The traditional medical practitioner in Zimbabwe: his principles of practice and pharmacopoeia. Cited 214 times.
  Mambo Press, Gweru
  

  •  
• 
  38

  Batista, R., De Jesus Silva Júnior, A., De Oliveira, A.B.

  Plant-derived antimalarial agents: New leads and efficient phytomedicines. part II. non-alkaloidal natural products
  (2009) Molecules, 14 (8), pp. 3037-3072. Cited 78 times.
  http://www.mdpi.com/1420-3049/14/8/3037/pdf
  doi: 10.3390/molecules14083037
  

  • View at Publisher
• 
  39

  Ojewole, J.A.O.

  Analgesic, anti-inflammatory and hypoglycaemic effects of Securidaca longepedunculata (Fresen.) [Polygalaceae] root-bark aqueous extract
  (2008) Inflammopharmacology, 16 (4), pp. 174-181. Cited 16 times.
  doi: 10.1007/s10787-007-0016-7
  

  • View at Publisher
• 
  40

  Moshi, M.J., Mbwambo, Z.H., Nondo, R.S.O., Masimba, P.J., Kapingu, M.C., Magelewanya, E.S.

  Anticonvulsant activity of Diospyros fischeri root extracts
  (2007) African Journal of Traditional, Complementary and Alternative Medicines, 4 (2), pp. 226-230. Cited 2 times.
  http://www.bioline.org.br/request?tc07021
  

  • View at Publisher
• 
  41

  Huang, R.-Q., Bell-Horner, C.L., Dibas, M.I., Covey, D.F., Drewe, J.A., Dillon, G.H.

  Pentylenetetrazole-induced inhibition of recombinant γ-aminobutyric acid type A (GABAA) receptors: Mechanism and site of action
  (2001) Journal of Pharmacology and Experimental Therapeutics, 298 (3), pp. 986-995. Cited 148 times.
  

  • View at Publisher
• 
  42

  Rang, H.P., Dale, M.M., Ritter, J.M., Moore, P.K.
  Antiepileptic drugs
  (2003) Pharmacology. Cited 14 times.
  Churchill Livingstone, Edinburgh
  

  •  
• 
  43

  Risa, J., Risa, A., Adsersen, A., Gauguin, B., Stafford, G.I., Van Staden, J., Jäger, A.K.

  Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay
  (2004) Journal of Ethnopharmacology, 93 (2-3), pp. 177-182. Cited 44 times.
  doi: 10.1016/j.jep.2004.01.021
  

  • View at Publisher
• 
  44

  Marchetti, C., Gavazzo, P., Stafford, G.I., Van Staden, J.

  South African plants used in traditional medicine to treat epilepsy have an antagonistic effect on NMDA receptor currents
  (2011) Journal of Ethnopharmacology, 137 (1), pp. 382-388. Cited 5 times.
  doi: 10.1016/j.jep.2011.05.038
  

  • View at Publisher
• 
  45

  Jäger, A.K., Mohoto, S.P., Van Heerden, F.R., Viljoen, A.M.

  Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay
  (2005) Journal of Ethnopharmacology, 96 (3), pp. 603-606. Cited 14 times.
  doi: 10.1016/j.jep.2004.10.005
  

  • View at Publisher
• 
  46

  Farnsworth, N.R., Soejarto, D.D.
  Global importance of medicinal plants
  (1991) The conservation of medicinal plants, pp. 25-51. Cited 171 times.
  Cambridge University Press, Cambridge, H.V. Akerele O, H. Synge (Eds.)
  

  •  
• 
  47

  Karki, M., Williams, J.T.
  (1999) Priority species of medicinal plants in South Asia. Medicinal and Aromatic Plants Program in Asia (MAPPA). Cited 3 times.
  IDRC/SARO, New Delhi, India
  

  •  
• 
  48

  (2015) World directory of minorities and indigenous peoples - India: overview, March 2009
  available at:, [accessed 23 April]
  http://www.refworld.org/docid/4954ce662.html
  

  •  
• 
  49

  Pushpangadan, P., Atal, C.K.

  Ethno-medico-botanical investigations in Kerala I. Some primitive tribals of western ghats and their herbal medicine
  (1984) Journal of Ethnopharmacology, 11 (1), pp. 59-77. Cited 65 times.
  doi: 10.1016/0378-8741(84)90096-5
  

  • View at Publisher
• 
  50

  Mahishi, P., Srinivasa, B.H., Shivanna, M.B.

  Medicinal plant wealth of local communities in some villages in Shimoga District of Karnataka, India
  (2005) Journal of Ethnopharmacology, 98 (3), pp. 307-312. Cited 58 times.
  doi: 10.1016/j.jep.2005.01.035
  

  • View at Publisher
• 
  51

  Sharma, J., Gairola, S., Gaur, R.D., Painuli, R.M., Siddiqi, T.O.

  Ethnomedicinal plants used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand, India
  (2013) Journal of Ethnopharmacology, 150 (1), pp. 353-370. Cited 15 times.
  doi: 10.1016/j.jep.2013.08.052
  

  • View at Publisher
• 
  52

  Chandrasekar, S., Bhanumathy, M., Pawar, A., Somasundaram, T.

  Phytopharmacology of Ficus religiosa
  (2010) Pharmacognosy Reviews, 4 (8), pp. 195-199. Cited 8 times.
  doi: 10.4103/0973-7847.70918
  

  • View at Publisher
• 
  53

  Singh, D., Goel, R.K.

  Anticonvulsant effect of Ficus religiosa: Role of serotonergic pathways
  (2009) Journal of Ethnopharmacology, 123 (2), pp. 330-334. Cited 43 times.
  doi: 10.1016/j.jep.2009.02.042
  

  • View at Publisher
• 
  54

  Singh, D., Singh, B., Goel, R.K.

  Traditional uses, phytochemistry and pharmacology of Ficus religiosa: A review
  (2011) Journal of Ethnopharmacology, 134 (3), pp. 565-583. Cited 31 times.
  doi: 10.1016/j.jep.2011.01.046
  

  • View at Publisher
• 
  55

  Rahmatullah, M., Hasan, A., Parvin, W., Moniruzzaman, M., Khatun, A., Khatun, Z., Jahan, F.I., (...), Jahan, R.

  Medicinal plants and formulations used by the Soren clan of the Santal tribe in Rajshahi District, Bangladesh for treatment of various ailments
  (2012) African Journal of Traditional, Complementary and Alternative Medicines, 9 (3), pp. 350-359. Cited 14 times.
  http://www.bioline.org.br/pdf?tc12048
  doi: 10.4314/ajtcam.v9i3.8
  

  • View at Publisher
• 
  56

  Sharafkhaneh, A., Velamuri, S., Badmaev, V., Lan, C., Hanania, N.

  The potential role of natural agents in treatment of airway inflammation
  (2007) Therapeutic Advances in Respiratory Disease, 1 (2), pp. 105-120. Cited 20 times.
  doi: 10.1177/1753465807086096
  

  • View at Publisher
• 
  57

  Rachchh, M., Jain, S.

  Gastroprotective effect of Benincasa hispida fruit extract
  (2008) Indian Journal of Pharmacology, 40 (6), pp. 271-275. Cited 33 times.
  doi: 10.4103/0253-7613.45154
  

  • View at Publisher
• 
  58

  Saxena, V.S., Nadkarni, V.V.

  Nonpharmacological treatment of epilepsy
  (2011) Annals of Indian Academy of Neurology, 14 (3), pp. 148-152. Cited 12 times.
  doi: 10.4103/0972-2327.85870
  

  • View at Publisher
• 
  59

  Parekar, R., Jadhav, K., Marathe, P., Rege, N.

  Effect of Saraswatarishta in animal models of behavior despair
  (2014) Journal of Ayurveda and Integrative Medicine, 5 (3), pp. 141-147. Cited 7 times.
  http://www.jaim.in/
  doi: 10.4103/0975-9476.140469
  

  • View at Publisher
• 
  60

  Moharana, D., Moharana, S.
  A clinical trial of Mentat in patients with various types of epilepsy
  (1994) Probe, 33, pp. 160-162. Cited 16 times.
  

  •  
• 
  61

  Sneader, W.

  Drug Discovery: A History
  (2006) Drug Discovery: A History, pp. 1-468. Cited 183 times.
  http://onlinelibrary.wiley.com/book/10.1002/0470015535
  ISBN: 978-047189979-2
  doi: 10.1002/0470015535
  

  • View at Publisher
• 
  62

  Samy, R.P., Gopalakrishnakone, P.
  Current status of herbal medicines and their future perspectives
  (2007) Nat Proc, 1176, pp. 1-13. Cited 14 times.
  

  •  
• 
  63

  Lai, C.-W., Lai, Y.-H.C.

  History of epilepsy in Chinese traditional medicine
  (1991) Epilepsia, 32 (3), pp. 299-302. Cited 28 times.
  

  • View at Publisher
• 
  64

  Ojemann, L.M., Nelson, W.L., Shin, D.S., Rowe, A.O., Buchanan, R.A.

  Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions
  (2006) Epilepsy and Behavior, 8 (2), pp. 376-383. Cited 71 times.
  doi: 10.1016/j.yebeh.2005.12.009
  

  • View at Publisher
• 
  65

  Yarnell, E., Abascal, K.

  An herbal formula for treating intractable epilepsy: A review of the literature
  (2000) Alternative and Complementary Therapies, 6 (4), pp. 203-206. Cited 5 times.
  

  • View at Publisher
• 
  66

  Narita, Y., Satowa, H., Kokubu, T., Sugaya, E.

  Treatment of epileptic patients with the Chinese herbal medicine 'Saiko-Keishi-To' (SK)
  (1982) IRCS Medical Science, 10 (2), pp. 88-89. Cited 10 times.
  
• 
  67

  Morello, G.
  Treating epilepsy effectively
  (1996) Am J Natural Med, 3, pp. 14-20.
  

  •  
• 
  68

  Park, J., Wei, H., Lawhon, D., Schachter, S.C.
  Herbal formulas in epilepsy: a systematic review. Joint Annual Meeting of the American Epilepsy Society/American Clinical Neurophysiology Society
  (2005) Epilepsia, 46, p. 215. Cited 3 times.
  

  •  
• 
  69

  Li, Q., Chen, X., He, L., Zhou, D.

  Traditional Chinese medicine for epilepsy
  (2009) Cochrane Database of Systematic Reviews, (3), art. no. CD006454. Cited 17 times.
  http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD006454/pdf_fs.html
  doi: 10.1002/14651858.CD006454.pub2
  

  • View at Publisher
• 
  70

  Li, C.M.
  Books originated from China and their effect to ancient Korea
  (2008) Proceedings of the 11th Academic Symposium of Chinese Medicine History and Literature, Guangxi, China
  [Chinese]
  

  •  
• 
  71

  Shim, E.B., Lee, S., Kim, J.Y., Earm, Y.E.

  Physiome and sasang constitutional medicine
  (2008) Journal of Physiological Sciences, 58 (7), pp. 433-440. Cited 32 times.
  doi: 10.2170/physiolsci.RV004208
  

  • View at Publisher
• 
  72

  Park, H.G., Yoon, S.Y., Choi, J.Y., Lee, G.S., Choi, J.H., Shin, C.Y., Son, K.H., (...), Cheong, J.H.

  Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis
  (2007) European Journal of Pharmacology, 574 (2-3), pp. 112-119. Cited 56 times.
  doi: 10.1016/j.ejphar.2007.07.011
  

  • View at Publisher
• 
  73

  Yeon, G.-M., Lee, Y.-J., Kim, Y.M., Nam, S.O.

  Combined use of conventional medicine with traditional Korean medicine to treat children with epilepsy
  (2014) Journal of Alternative and Complementary Medicine, 20 (6), pp. 461-465. Cited 2 times.
  www.liebertonline.com/acm
  doi: 10.1089/acm.2013.0429
  

  • View at Publisher
• 
  74

  Schachter, S.C.

  Complementary and alternative medical therapies
  (2008) Current Opinion in Neurology, 21 (2), pp. 184-189. Cited 25 times.
  doi: 10.1097/WCO.0b013e3282f47918
  

  • View at Publisher
• 
  75

  Elferink, J.G.R.

  Epilepsy and its treatment in the ancient cultures of America
  (1999) Epilepsia, 40 (7), pp. 1041-1046. Cited 15 times.
  http://www3.interscience.wiley.com/journal/117957420/issueyear?year=2009
  doi: 10.1111/j.1528-1157.1999.tb00815.x
  

  • View at Publisher
• 
  76

  Carod-Artal, F.J., Vázquez-Cabrera, C.B.

  An anthropological study about epilepsy in native tribes from central and south America
  (2007) Epilepsia, 48 (5), pp. 886-893. Cited 25 times.
  doi: 10.1111/j.1528-1167.2007.01016.x
  

  • View at Publisher
• 
  77

  Hillig, K.W.

  Genetic evidence for speciation in Cannabis (Cannabaceae)
  (2005) Genetic Resources and Crop Evolution, 52 (2), pp. 161-180. Cited 37 times.
  doi: 10.1007/s10722-003-4452-y
  

  • View at Publisher
• 
  78

  Mechoulam, R.
  The pharmacohistory of Cannabis sativa
  (1986) Cannabinoids as therapeutic agents, pp. 1-19. Cited 129 times.
  CRC Press, Boca Raton, FL, R. Mechoulam (Ed.)
  

  •  
• 
  79

  Li, H.L.
  An archaeological and historical account of Cannabis in China
  (1974) J Econ Bot, 28, pp. 437-448. Cited 4 times.
  

  •  
• 
  80

  Hanson, G.R., Venturelli, P.J., Fleckenstein, A.
  (2014) Drugs and society, p. 440. Cited 45 times.
  Jones & Bartlett Publishers, Burlington, MA
  

  •  

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