Effect of dehydroepiandrosterone administration in Chinese women over 37 years undergoing assisted reproductive techniques

European Journal of Obstetrics Gynecology and Reproductive Biology

Volume 202, 1 July 2016, Pages 9-13

 (Article)

Liu, X. , 

Wang, W., 

Wang, X., 

Qu, Q., 

Hao, C. 

 

Reproductive Medicine Center, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, 20 Yuhuangding East Rd, Yantai, Shandong, China 

View references (47)

Abstract

Objective To evaluate the effect of DHEA supplementation on in vitro fertilization (IVF) parameters and pregnancy outcomes in patients older than 37 years with normal ovarian reserve. Study design A retrospective cohort study was conducted to evaluate the impact of DHEA supplementation on IVF outcome of infertile women over 37 years with normal ovarian reserve between January 2012 and July 2014. 243 patients (study group) received 75 mg of DHEA daily (25 mg three times daily) before the IVF cycle. Another 243 patients (control group) received infertility treatment, but did not receive DHEA. The IVF outcome parameters in each group were compared. Results Both groups did not show statistically significant differences in terms of patient demographics characteristics, mean numbers of oocytes retrieved and mature oocytes rate. While patients in the DHEA group have the significantly higher implantation rate and live birth rate compared with controls (30.13% versus 22.70%, 43.33% versus 28.26%). We also found that the cycle cancellation rate and miscarriage rate were lower in the DHEA group (1.23% versus 5.34%, 13.33% versus 28.89%). Conclusion DHEA supplementation may significantly improve IVF outcomes in infertile women over the age of 37. © 2016 Elsevier Ireland Ltd. All rights reserved.

Author keywords

Dehydroepiandrosterone (DHEA); IVF parameters; Pregnancy rate

ISSN: 03012115 CODEN: EOGRASource Type: Journal Original language: English

DOI: 10.1016/j.ejogrb.2016.04.028Document Type: Article

Publisher: Elsevier Ireland Ltd

References (47)

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  Liu, X.; Reproductive Medicine Center, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, 20 Yuhuangding East Rd, China; email:xuemeiliu02@yeah.net
© Copyright 2016 Elsevier B.V., All rights reserved.