Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

BioFactors

Volume 40, Issue 1, January 2014, Pages 79-102

Santangelo, C. , 

Varì, R., 

Scazzocchio, B., 

Filesi, C., 

Masella, R.

 

Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, 00161, Italy 

View references (373)

Abstract

Obesity is a global and dramatic public health problem; maternal obesity represents one of the main risk factors of infertility and pregnancy complications as it is associated with adverse maternal and offspring outcomes. In the last few years, adipose tissue dysfunction associated with altered adipocytokine secretion has been suggested to play a critical role in all the phases of reproductive process. Obesity is a nutrition-related disorder. In this regard, dietary intervention strategies, such as high intake of fruit and vegetables, have shown significant effects in both preserving health and counteracting obesity-associated diseases. Evidence has been provided that polyphenols, important constituents of plant-derived food, can influence developmental program of oocyte and embryo, as well as pregnancy progression by modulating several cellular pathways. This review will examine the controversial results so far obtained on adipocytokine involvement in fertility impairment and pregnancy complications. Furthermore, the different effects exerted by polyphenols on oocyte, embryo, and pregnancy development will be also taken in account. © 2013 International Union of Biochemistry and Molecular Biology.

Author keywords

Adipocytokines; Bioavailability; Dietary polyphenols; Embryo; Gut microbiota; Male fertility; Mediterranean Diet; Oocyte; Phytoestrogens; Pregnancy

Indexed keywords

Medline keywords: adipocytokines; bioavailability; dietary polyphenols; embryo; gut microbiota; male fertility; Mediterranean Diet; oocyte; phytoestrogens; pregnancy
Medline is the source for the MeSH terms of this document.

MeSH: Animals; Anti-Obesity Agents; Diet; Female; Fertility; Humans; Inflammation Mediators; Obesity; Polyphenols; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Risk Factors
Medline is the source for the MeSH terms of this document.

ISSN: 09516433 CODEN: BIFAESource Type: Journal Original language: English

DOI: 10.1002/biof.1126 PubMed ID: 23983164Document Type: Review

References (373)

View in search results format

• Page
 
• • Export |
  • Print |
  • E-mail |
  • Create bibliography

• 
  1

  Catalano, P.M.

  Obesity, insulin resistance, and pregnancy outcome
  (2010) Reproduction, 140 (3), pp. 365-371. Cited 118 times.
  http://www.reproduction-online.org/cgi/reprint/140/3/365
  doi: 10.1530/REP-10-0088
  

  • View at Publisher
• 
  2

  Brewer, C.J., Balen, A.H.

  The adverse effects of obesity on conception and implantation
  (2010) Reproduction, 140 (3), pp. 347-364. Cited 142 times.
  http://www.reproduction-online.org/cgi/reprint/140/3/347
  doi: 10.1530/REP-09-0568
  

  • View at Publisher
• 
  3

  Sagae, S.C., Menezes, E.F., Bonfleur, M.L., Vanzela, E.C., Zacharias, P., Lubaczeuski, C., Franci, C.R., (...), Sanvitto, G.L.

  Early onset of obesity induces reproductive deficits in female rats
  (2012) Physiology and Behavior, 105 (5), pp. 1104-1111. Cited 13 times.
  doi: 10.1016/j.physbeh.2011.12.002
  

  • View at Publisher
• 
  4

  Tersigni, C., Di Nicuolo, F., D'Ippolito, S., Veglia, M., Castellucci, M., Di Simone, N.

  Adipokines: New emerging roles in fertility and reproduction
  (2011) Obstetrical and Gynecological Survey, 66 (1), pp. 47-63. Cited 17 times.
  doi: 10.1097/OGX.0b013e318217b0a4
  

  • View at Publisher
• 
  5

  Bohler Jr., H., Mokshagundam, S., Winters, S.J.

  Adipose tissue and reproduction in women
  (2010) Fertility and Sterility, 94 (3), pp. 795-825. Cited 35 times.
  doi: 10.1016/j.fertnstert.2009.03.079
  

  • View at Publisher
• 
  6

  Yilmaz, N., Kilic, S., Kanat-Pektas, M., Gulerman, C., Mollamahmutoglu, L.

  The relationship between obesity and fecundity
  (2009) Journal of Women's Health, 18 (5), pp. 633-636. Cited 24 times.
  doi: 10.1089/jwh.2008.1057
  

  • View at Publisher
• 
  7

  Van Der Steeg, J.W., Steures, P., Eijkemans, M.J.C., Habbema, J.D.F., Hompes, P.G.A., Burggraaff, J.M., Oosterhuis, G.J.E., (...), Mol, B.W.J.

  Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women
  (2008) Human Reproduction, 23 (2), pp. 324-328. Cited 147 times.
  doi: 10.1093/humrep/dem371
  

  • View at Publisher
• 
  8

  Grodstein, F., Goldman, M.B., Cramer, D.W.

  Body mass index and ovulatory infertility
  (1994) Epidemiology, 5 (2), pp. 247-250. Cited 173 times.
  

  • View at Publisher
• 
  9

  Lake, Power, C., Cole, T.J.

  Women's reproductive health: The role of body mass index in early and adult life
  (1997) International Journal of Obesity, 21 (6), pp. 432-438. Cited 143 times.
  
• 
  10

  Boots, C., Stephenson, M.D.

  Does obesity increase the risk of miscarriage in spontaneous conception: A systematic review
  (2011) Seminars in Reproductive Medicine, 29 (6), pp. 507-513. Cited 67 times.
  doi: 10.1055/s-0031-1293204
  

  • View at Publisher
• 
  11

  Maheshwari, A., Stofberg, L., Bhattacharya, S.

  Effect of overweight and obesity on assisted reproductive technology - A systematic review
  (2007) Human Reproduction Update, 13 (5), pp. 433-444. Cited 210 times.
  doi: 10.1093/humupd/dmm017
  

  • View at Publisher
• 
  12

  Pandey, S., Pandey, S., Maheshwari, A., Bhattacharya, S.

  The impact of female obesity on the outcome of fertility treatment
  (2010) Journal of Human Reproductive Sciences, 3 (2), pp. 62-67. Cited 30 times.
  doi: 10.4103/0974-1208.69332
  

  • View at Publisher
• 
  13

  Shah, D.K., Missmer, S.A., Berry, K.F., Racowsky, C., Ginsburg, E.S.

  Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization
  (2011) Obstetrics and Gynecology, 118 (1), pp. 63-70. Cited 66 times.
  doi: 10.1097/AOG.0b013e31821fd360
  

  • View at Publisher
• 
  14

  Moragianni, V.A., Jones, S.-M.L., Ryley, D.A.

  The effect of body mass index on the outcomes of first assisted reproductive technology cycles
  (2012) Fertility and Sterility, 98 (1), pp. 102-108. Cited 41 times.
  doi: 10.1016/j.fertnstert.2012.04.004
  

  • View at Publisher
• 
  15

  Bhattacharya, S., Campbell, D.M., Liston, W.A., Bhattacharya, S.

  Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies
  (2007) BMC Public Health, 7, art. no. 168. Cited 320 times.
  doi: 10.1186/1471-2458-7-168
  

  • View at Publisher
• 
  16

  Aly, H., Hammad, T., Nada, A., Mohamed, M., Bathgate, S., El-Mohandes, A.

  Maternal obesity, associated complications and risk of prematurity
  (2010) Journal of Perinatology, 30 (7), pp. 447-451. Cited 20 times.
  doi: 10.1038/jp.2009.117
  

  • View at Publisher
• 
  17

  Valsamakis, G., Kumar, S., Creatsas, G., Mastorakos, G.

  The effects of adipose tissue and adipocytokines in human pregnancy
  (2010) Annals of the New York Academy of Sciences, 1205, pp. 76-81. Cited 26 times.
  ISBN: 978-157331768-9
  doi: 10.1111/j.1749-6632.2010.05667.x
  

  • View at Publisher
• 
  18

  Simmons, D.

  Diabetes and obesity in pregnancy
  (2011) Best Practice and Research: Clinical Obstetrics and Gynaecology, 25 (1), pp. 25-36. Cited 34 times.
  doi: 10.1016/j.bpobgyn.2010.10.006
  

  • View at Publisher
• 
  19

  Han, S., Crowther, C.A., Middleton, P.

  Interventions for pregnant women with hyperglycaemia not meeting gestational diabetes and type 2 diabetes diagnostic criteria.
  (2012) Cochrane database of systematic reviews (Online), 1, p. CD009037. Cited 11 times.
  
• 
  20

  Li, M., Sloboda, D.M., Vickers, M.H.

  Maternal obesity and developmental programming of metabolic disorders in offspring: Evidence from animal models
  (2011) Experimental Diabetes Research, 2011, art. no. 592408. Cited 63 times.
  doi: 10.1155/2011/592408
  

  • View at Publisher
• 
  21

  Bouret, S.G.

  Early life origins of obesity: Role of hypothalamic programming
  (2009) Journal of Pediatric Gastroenterology and Nutrition, 48 (SUPPL. 1), pp. S31-S38. Cited 84 times.
  doi: 10.1097/MPG.0b013e3181977375
  

  • View at Publisher
• 
  22

  Heerwagen, M.J.R., Miller, M.R., Barbour, L.A., Friedman, J.E.

  Maternal obesity and fetal metabolic programming: A fertile epigenetic soil
  (2010) American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 299 (3), pp. R711-R722. Cited 188 times.
  http://ajpregu.physiology.org/cgi/reprint/299/3/R711
  doi: 10.1152/ajpregu.00310.2010
  

  • View at Publisher
• 
  23

  Barker, D.J.P., Martyn, C.N.

  The maternal and fetal origins of cardiovascular disease
  (1992) Journal of Epidemiology and Community Health, 46 (1), pp. 8-11. Cited 189 times.
  

  • View at Publisher
• 
  24

  Yessoufou, A., Moutairou, K.

  Maternal diabetes in pregnancy: Early and long-term outcomes on the offspring and the concept of "metabolic memory"
  (2011) Experimental Diabetes Research, 2011, art. no. 218598. Cited 64 times.
  doi: 10.1155/2011/218598
  

  • View at Publisher
• 
  25

  Robker, R.L., Wu, L.L.-Y., Yang, X.

  Inflammatory pathways linking obesity and ovarian dysfunction
  (2011) Journal of Reproductive Immunology, 88 (2), pp. 142-148. Cited 35 times.
  doi: 10.1016/j.jri.2011.01.008
  

  • View at Publisher
• 
  26

  Mutsaerts, M.A.Q., Groen, H., ter Bogt, N.C.W., Bolster, J.H.T., Land, J.A., Bemelmans, W.J.E., Kuchenbecker, W.K.H., (...), Hoek, A.

  The LIFESTYLE study: Costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial
  (2010) BMC Women's Health, 10, art. no. 22. Cited 22 times.
  http://www.biomedcentral.com/1472-6874/10/22
  doi: 10.1186/1472-6874-10-22
  

  • View at Publisher
• 
  27

  Chu, S.Y., Bachman, D.J., Callaghan, W.M., Whitlock, E.P., Dietz, P.M., Berg, C.J., O'Keeffe-Rosetti, M., (...), Hornbrook, M.C.

  Association between obesity during pregnancy and increased use of health care
  (2008) New England Journal of Medicine, 358 (14), pp. 1444-1453. Cited 125 times.
  http://content.nejm.org/cgi/reprint/358/14/1444.pdf
  doi: 10.1056/NEJMoa0706786
  

  • View at Publisher
• 
  28

  Lillycrop, K.A., Burdge, G.C.

  Epigenetic changes in early life and future risk of obesity
  (2011) International Journal of Obesity, 35 (1), pp. 72-83. Cited 78 times.
  doi: 10.1038/ijo.2010.122
  

  • View at Publisher
• 
  29

  Toledo, E., Lopez-Del Burgo, C., Ruiz-Zambrana, A., Donazar, M., Navarro-Blasco, I., Martínez-González, M.A., De Irala, J.

  Dietary patterns and difficulty conceiving: A nested case-control study
  (2011) Fertility and Sterility, 96 (5), pp. 1149-1153. Cited 17 times.
  doi: 10.1016/j.fertnstert.2011.08.034
  

  • View at Publisher
• 
  30

  Timmermans, S., Steegers-Theunissen, R.P.M., Vujkovic, M., Bakker, R., Den Breeijen, H., Raat, H., Russcher, H., (...), Steegers, E.A.P.

  Major dietary patterns and blood pressure patterns during pregnancy: The Generation R Study
  (2011) American Journal of Obstetrics and Gynecology, 205 (4), pp. 337.e1-337.e12. Cited 9 times.
  doi: 10.1016/j.ajog.2011.05.013
  

  • View at Publisher
• 
  31

  Symonds, M.E., Pope, M., Sharkey, D., Budge, H.

  Adipose tissue and fetal programming
  (2012) Diabetologia, 55 (6), pp. 1597-1606. Cited 42 times.
  doi: 10.1007/s00125-012-2505-5
  

  • View at Publisher
• 
  32

  Chatzi, L., Mendez, M., Garcia, R., Roumeliotaki, T., Ibarluzea, J., Tardón, A., Amiano, P., (...), Sunyer, J.

  Mediterranean diet adherence during pregnancy and fetal growth: INMA (Spain) and RHEA (Greece) mother-child cohort studies
  (2012) British Journal of Nutrition, 107 (1), pp. 135-145. Cited 23 times.
  doi: 10.1017/S0007114511002625
  

  • View at Publisher
• 
  33

  Finer, L.B., Zolna, M.R.

  Unintended pregnancy in the United States: Incidence and disparities, 2006
  (2011) Contraception, 84 (5), pp. 478-485. Cited 547 times.
  doi: 10.1016/j.contraception.2011.07.013
  

  • View at Publisher
• 
  34

  King, J.C.

  Physiology of pregnancy and nutrient metabolism
  (2000) American Journal of Clinical Nutrition, 71 (5 SUPPL.), pp. 1218S-1225S. Cited 158 times.
  

  • View at Publisher
• 
  35

  Adamo, K.B., Ferraro, Z.M., Brett, K.E.

  Can we modify the intrauterine environment to halt the intergenerational cycle of obesity?
  (2012) International Journal of Environmental Research and Public Health, 9 (4), pp. 1263-1307. Cited 41 times.
  http://www.mdpi.com/1660-4601/9/4/1263/pdf
  doi: 10.3390/ijerph9041263
  

  • View at Publisher
• 
  36

  Hirai, S., Takahashi, N., Goto, T., Lin, S., Uemura, T., Yu, R., Kawada, T.

  Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies
  (2010) Mediators of Inflammation, 2010, art. no. 367838. Cited 37 times.
  doi: 10.1155/2010/367838
  

  • View at Publisher
• 
  37

  González-Castejón, M., Rodriguez-Casado, A.

  Dietary phytochemicals and their potential effects on obesity: A review
  (2011) Pharmacological Research, 64 (5), pp. 438-455. Cited 82 times.
  doi: 10.1016/j.phrs.2011.07.004
  

  • View at Publisher
• 
  38

  Sears, B., Ricordi, C.

  Anti-inflammatory nutrition as a pharmacological approach to treat obesity
  (2011) Journal of Obesity, 2011, art. no. 431985. Cited 18 times.
  http://www.hindawi.com/journals/jobes/
  doi: 10.1155/2011/431985
  

  • View at Publisher
• 
  39

  Beunza, J.-J., Toledo, E., Hu, F.B., Bes-Rastrollo, M., Serrano-Martínez, M., Sánchez-Villegas, A., Martínez, J.A., (...), Martínez-González, M.A.

  Adherence to the Mediterranean diet, long-term weight change, and incident overweight or obesity: The Seguimiento Universidad de Navarra (SUN) cohort
  (2010) American Journal of Clinical Nutrition, 92 (6), pp. 1484-1493. Cited 62 times.
  http://www.ajcn.org/content/92/6/1484.full.pdf+html
  doi: 10.3945/ajcn.2010.29764
  

  • View at Publisher
• 
  40

  Herring, S.J., Rose, M.Z., Skouteris, H., Oken, E.

  Optimizing weight gain in pregnancy to prevent obesity in women and children
  (2012) Diabetes, Obesity and Metabolism, 14 (3), pp. 195-203. Cited 25 times.
  doi: 10.1111/j.1463-1326.2011.01489.x
  

  • View at Publisher
• 
  41

  Santangelo, C., Varì, R., Scazzocchio, B., Di Benedetto, R., Filesi, C., Masella, R.

  Polyphenols, intracellular signalling and inflammation
  (2007) Annali dell'Istituto Superiore di Sanita, 43 (4), pp. 394-405. Cited 139 times.
  
• 
  42

  Pérez-Jiménez, J., Neveu, V., Vos, F., Scalbert, A.

  Identification of the 100 richest dietary sources of polyphenols: An application of the Phenol-Explorer database
  (2010) European Journal of Clinical Nutrition, 64 (SUPPL. 3), pp. S112-S120. Cited 104 times.
  doi: 10.1038/ejcn.2010.221
  

  • View at Publisher
• 
  43

  Pérez-Jiménez, J., Fezeu, L., Touvier, M., Arnault, N., Manach, C., Hercberg, S., Galan, P., (...), Scalbert, A.

  Dietary intake of 337 polyphenols in French adults
  (2011) American Journal of Clinical Nutrition, 93 (6), pp. 1220-1228. Cited 127 times.
  http://www.ajcn.org/content/93/6/1220.full.pdf+html
  doi: 10.3945/ajcn.110.007096
  

  • View at Publisher
• 
  44

  Fenech, M., El-Sohemy, A., Cahill, L., Ferguson, L.R., French, T.-A.C., Tai, E.S., Milner, J., (...), Head, R.

  Nutrigenetics and nutrigenomics: Viewpoints on the current status and applications in nutrition research and practice
  (2011) Journal of Nutrigenetics and Nutrigenomics, 4 (2), pp. 69-89. Cited 61 times.
  doi: 10.1159/000327772
  

  • View at Publisher
• 
  45

  Bouchard, C., Ordovas, J.M.

  Fundamentals of nutrigenetics and nutrigenomics
  (2012) Progress in Molecular Biology and Translational Science, 108, pp. 1-15. Cited 15 times.
  doi: 10.1016/B978-0-12-398397-8.00001-0
  

  • View at Publisher
• 
  46

  Szarc vel Szic, K., Ndlovu, M.N., Haegeman, G., Vanden Berghe, W.

  Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders
  (2010) Biochemical Pharmacology, 80 (12), pp. 1816-1832. Cited 68 times.
  doi: 10.1016/j.bcp.2010.07.029
  

  • View at Publisher
• 
  47

  Rooney, K., Ozanne, S.E.

  Maternal over-nutrition and offspring obesity predisposition: Targets for preventative interventions
  (2011) International Journal of Obesity, 35 (7), pp. 883-890. Cited 53 times.
  doi: 10.1038/ijo.2011.96
  

  • View at Publisher
• 
  48

  Chuang, C.-C., McIntosh, M.K.

  Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases
  (2011) Annual Review of Nutrition, 31, pp. 155-176. Cited 55 times.
  doi: 10.1146/annurev-nutr-072610-145149
  

  • View at Publisher
• 
  49

  D'Ippolito, S., Tersigni, C., Scambia, G., Di Simone, N.

  Adipokines, an adipose tissue and placental product with biological functions during pregnancy
  (2012) BioFactors, 38 (1), pp. 14-23. Cited 22 times.
  doi: 10.1002/biof.201
  

  • View at Publisher
• 
  50

  Bernal, A.B., Vickers, M.H., Hampton, M.B., Poynton, R.A., Sloboda, D.M.

  Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring
  (2010) PLoS ONE, 5 (12), art. no. e15558. Cited 46 times.
  http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0015558&representation=PDF
  doi: 10.1371/journal.pone.0015558
  

  • View at Publisher
• 
  51

  Igosheva, N., Abramov, A.Y., Poston, L., Eckert, J.J., Fleming, T.P., Duchen, M.R., McConnell, J.

  Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes
  (2010) PLoS ONE, 5 (4), art. no. e10074. Cited 151 times.
  http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0010074&representation=PDF
  doi: 10.1371/journal.pone.0010074
  

  • View at Publisher
• 
  52

  Hotamisligil, G.S.

  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
  (2010) Cell, 140 (6), pp. 900-917. Cited 940 times.
  doi: 10.1016/j.cell.2010.02.034
  

  • View at Publisher
• 
  53

  Gnacińska, M., Małgorzewicz, S., Stojek, M., Łysiak-Szydłowska, W., Sworczak, K.

  Role of adipokines in complications related to obesity. A review
  (2009) Advances in Medical Sciences, 54 (2), pp. 150-157. Cited 84 times.
  doi: 10.2478/v10039-009-0035-2
  

  • View at Publisher
• 
  54

  Lecke, S.B., Morsch, D.M., Spritzer, P.M.

  Leptin and adiponectin in the female life course
  (2011) Brazilian Journal of Medical and Biological Research, 44 (5), pp. 381-387. Cited 12 times.
  http://www.scielo.br/pdf/bjmbr/v44n5/954.pdf
  doi: 10.1590/S0100-879X2011007500035
  

  • View at Publisher
• 
  55

  Boydens, C., Maenhaut, N., Pauwels, B., Decaluwé, K., Van De Voorde, J.

  Adipose tissue as regulator of vascular tone
  (2012) Current Hypertension Reports, 14 (3), pp. 270-278. Cited 18 times.
  doi: 10.1007/s11906-012-0259-6
  

  • View at Publisher
• 
  56

  Campos, D.B., Palin, M.-F., Bordignon, V., Murphy, B.D.

  The 'beneficial' adipokines in reproduction and fertility
  (2008) International Journal of Obesity, 32 (2), pp. 223-231. Cited 64 times.
  doi: 10.1038/sj.ijo.0803719
  

  • View at Publisher
• 
  57

  Briana, D.D., Malamitsi-Puchner, A.

  Reviews: Adipocytokines in normal and complicated pregnancies
  (2009) Reproductive Sciences, 16 (10), pp. 921-937. Cited 68 times.
  doi: 10.1177/1933719109336614
  

  • View at Publisher
• 
  58

  Luke, B., Brown, M.B., Missmer, S.A., Bukulmez, O., Leach, R., Stern, J.E.

  The effect of increasing obesity on the response to and outcome of assisted reproductive technology: A national study
  (2011) Fertility and Sterility, 96 (4), pp. 820-825. Cited 34 times.
  doi: 10.1016/j.fertnstert.2011.07.1100
  

  • View at Publisher
• 
  59

  Hotamisligil, G.S.

  Inflammation and metabolic disorders
  (2006) Nature, 444 (7121), pp. 860-867. Cited 3125 times.
  doi: 10.1038/nature05485
  

  • View at Publisher
• 
  60

  Schäffler, A., Schölmerich, J.

  Innate immunity and adipose tissue biology
  (2010) Trends in Immunology, 31 (6), pp. 228-235. Cited 91 times.
  doi: 10.1016/j.it.2010.03.001
  

  • View at Publisher
• 
  61

  Inadera, H.

  The usefulness of circulating adipokine levels for the assessment of obesity-related health problems
  (2008) International Journal of Medical Sciences, 5 (5), pp. 248-262. Cited 55 times.
  http://www.medsci.org/v05p0248.pdf
  

  • View at Publisher
• 
  62

  Zaadstra, B.M., Seidell, J.C., Van Noord, P.A.H., Te Velde, E.R., Habbema, J.D.F., Vrieswijk, B., Karbaat, J.

  Fat and female fecundity: Prospective study of effect of body fat distribution on conception rates
  (1993) British Medical Journal, 306 (6876), pp. 484-487. Cited 382 times.
  

  • View at Publisher
• 
  63

  Maury, E., Brichard, S.M.

  Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
  (2010) Molecular and Cellular Endocrinology, 314 (1), pp. 1-16. Cited 397 times.
  doi: 10.1016/j.mce.2009.07.031
  

  • View at Publisher
• 
  64

  Briana, D.D., Malamitsi-Puchner, A.

  The role of adipocytokines in fetal growth
  (2010) Annals of the New York Academy of Sciences, 1205, pp. 82-87. Cited 31 times.
  ISBN: 978-157331768-9
  doi: 10.1111/j.1749-6632.2010.05650.x
  

  • View at Publisher
• 
  65

  Wendremaire, M., Bardou, M., Peyronel, C., Hadi, T., Sagot, P., Morrison, J.J., Lirussi, F.

  Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis
  (2011) American Journal of Obstetrics and Gynecology, 205 (4), pp. 363.e1-363.e9. Cited 5 times.
  doi: 10.1016/j.ajog.2011.05.041
  

  • View at Publisher
• 
  66

  Orsi, N.M., Tribe, R.M.

  Cytokine Networks and the regulation of uterine function in pregnancy and parturition
  (2008) Journal of Neuroendocrinology, 20 (4), pp. 462-469. Cited 70 times.
  doi: 10.1111/j.1365-2826.2008.01668.x
  

  • View at Publisher
• 
  67

  Huang, X., Huang, H., Dong, M., Yao, Q., Wang, H.

  Serum and placental interleukin-18 are elevated in preeclampsia
  (2005) Journal of Reproductive Immunology, 65 (1), pp. 77-87. Cited 29 times.
  doi: 10.1016/j.jri.2004.09.003
  

  • View at Publisher
• 
  68

  Duggal, P.S., Van Der Hoek, K.H., Milner, C.R., Ryan, N.K., Armstrong, D.T., Magoffin, D.A., Norman, R.J.

  The in vivo and in vitro effects of exogenous leptin on ovulation in the rat
  (2000) Endocrinology, 141 (6), pp. 1971-1976. Cited 132 times.
  doi: 10.1210/en.141.6.1971
  

  • View at Publisher
• 
  69

  Swain, J.E., Dunn, R.L., McConnell, D., Gonzalez-Martinez, J., Smith, G.D.

  Direct effects of leptin on mouse reproductive function: Regulation of follicular, oocyte, and embryo development
  (2004) Biology of Reproduction, 71 (5), pp. 1446-1452. Cited 56 times.
  doi: 10.1095/biolreprod.104.033035
  

  • View at Publisher
• 
  70

  Silva, E., Paczkowski, M., Krisher, R.L.

  The effect of leptin on maturing porcine oocytes is dependent on glucose concentration
  (2012) Molecular Reproduction and Development, 79 (4), pp. 296-307. Cited 8 times.
  doi: 10.1002/mrd.22029
  

  • View at Publisher
• 
  71

  Svendsen, P.F., Christiansen, M., Hedley, P.L., Nilas, L., Pedersen, S.B., Madsbad, S.

  Adipose expression of adipocytokines in women with polycystic ovary syndrome
  (2012) Fertility and Sterility, 98 (1), pp. 235-241. Cited 24 times.
  doi: 10.1016/j.fertnstert.2012.03.056
  

  • View at Publisher
• 
  72

  Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Nakamura, A., (...), Tanaka, T.

  Leptin promotes the development of mouse preimplantation embryos in vitro
  (2002) Endocrinology, 143 (5), pp. 1922-1931. Cited 100 times.
  doi: 10.1210/en.143.5.1922
  

  • View at Publisher
• 
  73

  Dos Santos, E., Serazin, V., Morvan, C., Torre, A., Wainer, R., De Mazancourt, P., Dieudonné, M.-N.

  Adiponectin and leptin systems in human endometrium during window of implantation
  (2012) Fertility and Sterility, 97 (3), pp. 771-778.e1. Cited 32 times.
  doi: 10.1016/j.fertnstert.2011.12.042
  

  • View at Publisher
• 
  74

  Marchini, G., Fried, G., Östlund, E., Hagenäs, L.

  Plasma leptin in infants: Relations to birth weight and weight loss
  (1998) Pediatrics, 101 (3 I), pp. 429-432. Cited 83 times.
  doi: 10.1542/peds.101.3.429
  

  • View at Publisher
• 
  75

  Highman, T.J., Friedman, J.E., Huston, L.P., Wong, W.W., Catalano, P.M.

  Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy
  (1998) American Journal of Obstetrics and Gynecology, 178 (5), pp. 1010-1015. Cited 169 times.
  doi: 10.1016/S0002-9378(98)70540-X
  

  • View at Publisher
• 
  76

  Misra, V.K., Trudeau, S.

  The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy
  (2011) Obesity, 19 (2), pp. 416-421. Cited 24 times.
  doi: 10.1038/oby.2010.172
  

  • View at Publisher
• 
  77

  Hendler, I., Blackwell, S.C., Mehta, S.H., Whitty, J.E., Russell, E., Sorokin, Y., Cotton, D.B.

  The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia
  (2005) American Journal of Obstetrics and Gynecology, 193 (3 SUPPL.), pp. 979-983. Cited 144 times.
  doi: 10.1016/j.ajog.2005.06.041
  

  • View at Publisher
• 
  78

  Vrachnis, N., Belitsos, P., Sifakis, S., Dafopoulos, K., Siristatidis, C., Pappa, K.I., Iliodromiti, Z.

  Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus
  (2012) International Journal of Endocrinology, 2012, art. no. 549748. Cited 24 times.
  doi: 10.1155/2012/549748
  

  • View at Publisher
• 
  79

  Liu, Y.-H., Tsai, E.-M., Wu, L.-C., Chen, S.-Y., Chang, Y.-H., Jong, S.-B., Chan, T.-F.

  Higher basal adiponectin levels are associated with better ovarian response to gonadotropin stimulation during in vitro fertilization
  (2005) Gynecologic and Obstetric Investigation, 60 (3), pp. 167-170. Cited 9 times.
  doi: 10.1159/000086633
  

  • View at Publisher
• 
  80

  Toulis, K.A., Goulis, D.G., Farmakiotis, D., Georgopoulos, N.A., Katsikis, I., Tarlatzis, B.C., Papadimas, I., (...), Panidis, D.

  Adiponectin levels in women with polycystic ovary syndrome: A systematic review and a meta-analysis
  (2009) Human Reproduction Update, 15 (3), pp. 297-307. Cited 113 times.
  doi: 10.1093/humupd/dmp006
  

  • View at Publisher

  Santangelo, C.; Viale Regina Elena 299, 00161 Rome, Italy; email:carmela.santangelo@iss.it
© Copyright 2014 Elsevier B.V., All rights reserved.