Two activators of in vitro fertilization in mice from licorice

Biochemical and Biophysical Research Communications

Volume 467, Issue 2, 13 November 2015, Pages 447-450

  (Article)

Tung, N.H.^ac, 

Shoyama, Y.^a, 

Wada, M.^b, 

Tanaka, H.^b 

 

^a  Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, Japan
^b  Molecular Biology Laboratories, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, Japan
^c  School of and Pharmacy, Vietnam National University, 144 Xuan Thuy, Cau Giay, Hanoi, Viet Nam 

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Abstract

Systems for artificial insemination have been established in some animals. However, due to limited availability of sperm and oocytes, more effective treatment methodologies are required. Recently, it was demonstrated that the rate of in vitro fertilization (IVF) in mice was improved by adding a water extract of licorice (Glycyrrhiza uralensis), but not glycyrrhizic acid, to the artificial insemination culture medium. In this study, we examined licorice extract for active compounds using bioassay-guided separation. The results indicated that isoliquiritigenin and formononetin were the active molecules in licorice that contributed to the improved rate of IVF. © 2015 The Authors. Published by Elsevier Inc.

Author keywords

Assisted reproductive technology (ART); Flavonoid; Formononetin; Glycyrrhizin; Insemination; Isoliquiritigenin; Licorice; Polyphenol; Sperm

Indexed keywords

EMTREE drug terms: fertility promoting agent; formononetin; isoliquiritigenin; plant extract; chalcone derivative; formononetin; isoflavone derivative; isoliquiritigenin; plant extract; seric gonadotropin

EMTREE medical terms: animal tissue; Article; artificial insemination; drug isolation; embryo; embryo development; female; fertilization; fertilization in vitro; Glycyrrhiza; male; mouse; nonhuman; oocyte; priority journal; sperm; animal; animal embryo; Bagg albino mouse; chemistry; cumulus cell; cytology; drug effects; fertilization in vitro; Glycyrrhiza uralensis; horse; Institute for Cancer Research mouse; isolation and purification; plant root; spermatozoon

MeSH: Animals; Chalcones; Cumulus Cells; Embryo, Mammalian; Female; Fertilization in Vitro; Glycyrrhiza uralensis; Gonadotropins, Equine; Horses; Isoflavones; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oocytes; Plant Extracts; Plant Roots; Spermatozoa
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: formononetin, 485-72-3; isoliquiritigenin, 29913-71-1, 961-29-5; seric gonadotropin, 9002-70-4;Chalcones; formononetin; Gonadotropins, Equine; Isoflavones; isoliquiritigenin; Plant Extracts

ISSN: 0006291X CODEN: BBRCASource Type: Journal Original language: English

DOI: 10.1016/j.bbrc.2015.09.088 PubMed ID: 26392313Document Type: Article

Publisher: Academic Press Inc.

References (14)

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  Tanaka, H.; Molecular Biology Laboratories, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Japan
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