(Article)
a Robert Koch-Institute, German Reference Center for Staphylococci and Enterococci, Wernigerode Burgstraße 37, Wernigerode, Germany
b Institute of Medical Microbiology, University Hospital Münster, Domagkstraße 10, Münster, Germany
c Tierärztliche Klinik für Pferde, Domäne Karthaus, Weddern 16c, Dülmen Dülmen, Germany
b Institute of Medical Microbiology, University Hospital Münster, Domagkstraße 10, Münster, Germany
c Tierärztliche Klinik für Pferde, Domäne Karthaus, Weddern 16c, Dülmen Dülmen, Germany
Abstract
A total of 272 methicillin-resistant Staphylococcus aureus (MRSA) from equine infections originating from 17 equine hospitals and 39 veterinary practices in Germany as well as 67 isolates from personnel working at equine clinics were subjected to molecular typing. The majority of isolates from horses was attributed to clonal complex (CC) 398 (82.7%). Within CC398, 66% of isolates belonged to a subpopulation (clade) of CC398, which is associated with equine clinics. MRSA attributed to CC8 (ST254, t009, t036, SCC. mecIV; ST8, t064, SCC. mecIV) were less frequent (16.5%). Single isolates were attributed to ST1, CC22, ST130, and ST1660. The emergence of MRSA CC22 and ST130 in horses was not reported so far. Nasal MRSA colonization was found in 19.5% of veterinary personnel with occupational exposure to horses. The typing characteristics of these isolates corresponded to isolates from equine infections. Comparing typing characteristics of equine isolates with those of a substantial number of isolates from human infections typed at the German Reference Center for Staphylococci and Enterococci (2006-2014; n=10864) yielded that the proportion of isolates exhibiting characteristics of MRSA from equine medicine is very low (<. 0.5%). As this low proportion was also found among MRSA originating from nasal screenings of human carriers not suffering from a staphylococcal infection (n=5546) transmission of MRSA from equine clinics to the community seems to be rare so far. © 2015 The Authors.
Author keywords
Equine clinic associated MRSA; Host specificity; MRSA; Zoonotic transmission
Indexed keywords
EMTREE drug terms: ciprofloxacin; clindamycin; cotrimoxazole; daptomycin; erythromycin; fosfomycin; fusidic acid; gentamicin; linezolid; moxifloxacin; oxacillin; penicillin derivative; polypeptide antibiotic agent; pseudomonic acid; rifampicin; teicoplanin; tetracycline; tigecycline; vancomycin
EMTREE medical terms: antibiotic sensitivity; Article; bacterial colonization; bacterial count; bacterial strain; bacterial transmission; bacterium carrier; bacterium isolate; cladistics; controlled study; Germany; health care personnel; horse disease; human; major clinical study; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; molecular cloning; molecular typing; nonhuman; occupational exposure; prospective study; veterinarian; veterinary clinic
Chemicals and CAS Registry Numbers: ciprofloxacin, 85721-33-1; clindamycin, 18323-44-9; cotrimoxazole, 8064-90-2; daptomycin, 103060-53-3; erythromycin, 114-07-8, 70536-18-4; fosfomycin, 23155-02-4; fusidic acid, 6990-06-3; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; linezolid, 165800-03-3; moxifloxacin, 151096-09-2; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; pseudomonic acid, 12650-69-0, 40980-51-6, 71980-98-8; rifampicin, 13292-46-1; teicoplanin, 61036-62-2, 61036-64-4; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; tigecycline, 220620-09-7; vancomycin, 1404-90-6, 1404-93-9
ISSN: 23527714Source Type: Journal Original language: English
DOI: 10.1016/j.onehlt.2015.11.004Document Type: Article
Publisher: Elsevier
Cuny, C.; Robert Koch-Institute, German Reference Center for Staphylococci and Enterococci, Wernigerode Burgstraße 37, Germany; email:Cunych@rki.de
© Copyright 2016 Elsevier B.V., All rights reserved.
© Copyright 2016 Elsevier B.V., All rights reserved.