- 1a Department of Comparative Medicine , Medical University of South Carolina , Charleston , South Carolina , USA.
- 2b Ralph H. Johnson VA Medical Center Department of Research Service , Charleston , South Carolina , USA.
- 3c
Department of Medicine , Nutrition Section, Division of
Gastroenterology, Medical University of South Carolina , Charleston ,
South Carolina , USA.
- 4d Department of Medicine ,
Infectious Disease Division, Medical University of South Carolina ,
Charleston , South Carolina , USA.
- 5e Department of
Psychiatry , Nutrition Section, Division of Gastroenterology, Medical
University of South Carolina , Charleston , South Carolina , USA.
Abstract
Controversy
continues concerning antimicrobial use in food animals and its
relationship to drug-resistant infections in humans. We systematically
reviewed published literature for evidence of a relationship between
antimicrobial use in agricultural animals and drug-resistant meat or
dairy-borne non-typhoidal salmonellosis in humans. Based on publications
from the United States (U.S.), Canada, and Denmark from January 2010 to
July 2014, 858 articles received title and abstract review, 104 met
study criteria for full article review with 68 retained for which data
are presented. Antibiotic exposure in both cattle and humans found an
increased likelihood of Salmonella colonization, whereas in chickens,
animals not exposed to antibiotics (organic)
were more likely to be Salmonella positive and those that had
antibiotic exposure were more likely to harbor antimicrobial resistant
Salmonella organisms. In swine
literature, only tylosin exposure was examined and no correlation was
found among exposure, Salmonella colonization, or antimicrobial
resistance. No studies that identified farm antimicrobial use also
traced antimicrobial-resistant Salmonella from farm to fork.
KEYWORDS:
Food safety; farm-to-fork; meat; streptomycin; tetracycline
