Influence of peroral application of a herbal immunomodulator on the antibody production of Peyer's patches cells.
- 1Schaper & Brümmer GmbH & Co. KG, Research and Development, Salzgitter, Germany. cornelia.bodinet@schaper-bruemmer.de
Abstract
The influence of the peroral administration of the macromolecular components of a herbal immunomodulator isolated from an aqueous-ethanolic extract of the mixed herbal
drugs Thujae summitates, Baptisiae tinctoriae radix, Echinaceae
purpureae radix and Echinaceae pallidae radix on the function of Peyer's
patches cells was investigated in mice. Peyer's patches cells isolated
from mice which had received oral administration of the macromolecular
fraction of the plant extract developed a significantly enhanced
plaque-forming cell (PFC) response to sheep
red blood cells after incubation with these cells in the presence of
lipopolysaccharide or the extract fraction for 7 days in vitro. These
results show that after oral administration of the herbal
immunomodulator, the immunologically active macromolecules can contact
the cells of the gut-associated lymphoid tissue and modulate the mucosal
immune response.
