Article Number - 822E8F155344
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Full Length Research Paper
Ricardo Carvalho dos Santos*
Antonio Alves de Melo Filho
Edvan Alves Chagas
Jacqueline Aparecida Takahashi
Vany Perpetua Ferraz
Ismael Montero Fernández
Pedro Romulo Estevam Ribeiro
Ana Cristina Gonçalves Reis de Melo
Luciana Chaves Holanda
- Abstract
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Lantana camara L. is considered a weed, but is used in agriculture and traditional medicine due to its different pharmacological effects. The objective of this study was to determine the chemical composition and the bioactivity of essential oil from L. camara flowers collected in Boa Vista, Roraima, Brazil. Essential oil was obtained using a Clevenger type apparatus. The oil obtained was analyzed by gas chromatography coupled to flame ionization detector (GC-FID) and gas chromatography coupled to mass spectrometer detector (GC-MS) and its bioactivity was assayed against fungi and bacteria, as well as for acetylcholinesterase inhibition. The chemical composition of essential oil presented major compounds contrasting with the literature, while its bactericidal and fungicidal activity was excellent, reaching over than 90% inhibition against yeast. A potent anti-acetylcholinesterase activity, superior than 77% inhibition, was also observed.
Keywords: Lantana camara, flowers essential oil, antiacetylcholinesterase, antimicrobial
Abbreviation:
AChE, Acetycholinesterase; GC-FID, gas chromatography using flame ionization detector; AD, Alzheimer's disease.