Volume 67, January 2015, Pages 199–205
Highlights
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- The red table wine showed a much higher reducing capacity than the Port wines.
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- The FRAP assay, but not DPPH, seems to be correlated with the levels of phenolics.
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- The Vintage Port was the most effective in inhibiting MKN-28 cell proliferation.
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- Procyanidins from fractions FII seem to play a role in the antiproliferative action.
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- The 20-year-old Tawny Port still showed some bioactivity in all cell lines used.
Abstract
This
study is focused on the impact of Port wine ageing on some antioxidant
features and antiproliferative properties towards human cancer cells.
For this, two types of Port wines with different ageing stages were
used: a young Vintage and a 20-year-old Tawny. The wines were
dealcoholized and two wine phenolic fractions were also characterized
and tested. The radical scavenging capacity was similar amongst the
wines tested but the reducing capacity was significantly reduced for
both Port wine extracts. The results from the FRAP assay, but not DPPH,
seem to be positively correlated with the amounts of phenolics with
lower structural complexity.
MKN-28 (stomach) was
found to be the most susceptible cell line to the antiproliferative
effect of the young Vintage Port. However, for all wines, Caco-2 (colon)
was the cell line that showed the lowest IC50. Interestingly, the old Tawny Port was found to maintain some antiproliferative activity.
Keywords
- Antioxidant;
- Antiproliferative;
- Port wine;
- Ageing;
- Polyphenols
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