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Article in press 
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a Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
b Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
b Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
Abstract
Bryophyllum pinnatum (syn. Kalanchoe pinnata) is a succulent perennial plant native to Madagascar that was introduced in anthroposophic medicine in the early 20th century. In recent years, we conducted a large collaborative project to provide reliable data on the chemical composition, pharmacological properties, and clinical efficacy of Bryophyllum. Here, we comprehensively review the phytochemistry, as well as the pharmacological and clinical data. As to the pharmacology, special emphasis is given to properties related to the use in anthroposophic medicine as a treatment for “hyperactivity diseases”, such as preterm labor, restlessness, and sleep disorders. Studies suggesting that B. pinnatum may become a new treatment option for overactive bladder syndrome are also reviewed. Tolerability is addressed, and toxicological data are discussed in conjunction with the presence of potentially toxic bufadienolides in Bryophyllum species. The few data available on tworelated species with medicinal uses, Bryophyllum daigremontianum and Bryophyllum delagoense, have also been included. Taken together, current data support the use of B. pinnatum for the mentioned indications, but further studies are needed to fully understand the modes of action, and to identify the pharmacologically active constituents. Copyright © 2016, Georg Thieme Verlag KG. All rights reserved.
Author keywords
anthroposophic medicine; Bryophyllum daigremontianum; Bryophyllum delagoense; Bryophyllumpinnatum; clinical studies; constituents; Crassulaceae; pharmacological activities
ISSN: 00320943 CODEN: PLMEASource Type: Journal Original language: English
DOI: 10.1055/s-0042-106727Document Type: Article in Press
Publisher: Georg Thieme Verlag
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Potterat, O.; Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstraße 50, CH-4056 Basel, Switzerland, ; email:Olivier.Potterat@unibas.ch
© Copyright 2016 Elsevier B.V., All rights reserved.
© Copyright 2016 Elsevier B.V., All rights reserved.