Plastotoma rotundifolium aerial tissue extract has antibacterial activities

Industrial Crops and Products

Volume 86, August 01, 2016, Pages 301-310

  (Article)

Ngezahayo, J.^ab , 

Pottier, L.^a, 

Ribeiro, S.O.^a, 

Delporte, C.^c, 

Fontaine, V.^d, 

Hari, L.^b, 

Stévigny, C.^a, 

Duez, P.^ae

 

^a  Laboratoire de Pharmacognosie, Bromatologie et Nutrition humaine, Faculté de Pharmacie, Université Libre de Bruxelles, CP 205/09, Boulevard du Triomphe, Bruxelles, Belgium
^b  Centre de Recherche Universitaire en Pharmacopée et Medecine Traditionnelle (CRUPHAMET), Faculté des Sciences, Université du Burundi, BP. 2700, Bujumbura, Burundi
^c  Laboratoire de Chimie Pharmaceutique et Plateforme Analytique, Faculté de Pharmacie, Université Libre de Bruxelles, CP 205/05, Boulevard du Triomphe, Bruxelles, Belgium 

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Abstract

Despite efforts in recent years, infectious diseases remain a worldwide major public health problem. Several infectious agents have become resistant to conventional antibiotics and there is thus urgent need to discover new antimicrobial drugs to overcome resistances. Platostoma rotundifolium (Briq.) A. J. Paton, an African plant, is mainly used to treat microbial infections in traditional Burundian medicine. From the ethyl acetate extract of the aerial parts, five pentacyclic triterpenoid acids were isolated and characterized. Based on spectral analysis, these compounds were elucidated to be 2α, 3α, 19β-trihydroxyurs-12-en-28-oic acid (that was named jeremic acid) (1), 3β-hydroxyurs-12-en-28-oic acid (ursolic acid) (2), 2α, 3β-dihydroxyurs-12-en-28-oic acid (corosolic acid) (3), 2α, 3β, 19α-trihydroxyurs-2-en-28-oic acid (tormentic acid) (4) and 19-hydroxy-2-hydroxymethyl norursa-2, 12-dien-28-oic acid (hyptadienic acid) (5). Ursolic (MIC = 17.5-68 μM) and corosolic (MIC = 17-68 μM) acids showed significant antibacterial activities against both the Gram-positive Staphylococcus aureus(methicillin-susceptible and -resistant strains) and the Gram-negative Escherichia coli, which may substantiate the use of P. rotundifolium in traditional Burundian medicine. Such hydroxylated pentacyclic triterpenoid acids could point to new antimicrobial strategies that may help overcoming the antimicrobial resistances actually observed throughout the world. © 2016 Elsevier B.V.

Author keywords

Antibacterial activity; Bioautography; Lamiaceae; MRSA; Pentacyclic triterpenoids; Platostoma rotundifolium

Indexed keywords

Engineering controlled terms: Antimicrobial agents; Bacteria; Escherichia coli; Essential oils; Microorganisms; Spectrum analysis

Anti-bacterial activity; Bioautography; Lamiaceae; MRSA; Pentacyclic triterpenoids; Platostoma rotundifolium

Engineering main heading: Plants (botany)

Species Index: Escherichia coli; Lamiaceae; methicillin resistant Staphylococcus aureus; Negibacteria; Platostoma rotundifolium; Posibacteria; Staphylococcus aureus

ISSN: 09266690 CODEN: ICRDESource Type: Journal Original language: English

DOI: 10.1016/j.indcrop.2016.04.004Document Type: Article

Publisher: Elsevier

References (59)

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  Ngezahayo, J.; Laboratoire de Pharmacognosie, Bromatologie et Nutrition humaine, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine-CP205/9, Boulevard du Triomphe, Belgium; email:jngezaha@ulb.ac.be
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