New natural supplement relieves canine arthritis
Date:
November 10, 2014
Source:
Universite de Montreal
http://www.sciencedaily.com/releases/2014/11/141110082225.htm
Summary:
Arthritis pain in dogs can be
relieved, with no side effects, by a new product based on medicinal
plants and dietary supplements. Two formulas were developed. The first
formula, composed of curcumin, devil's claw, black current, Indian
frankincense (Salai), willow bark, pineapple bromelaine and camomile,
was developed to treat arthritis-induced inflammation. The second
included the same ingredients, plus dietary supplements such as omega 3,
chondroitin sulfate and glutamine, and was formulated in the hope that
it would promote the regeneration of articulations.
Portrait old dog
Credit: © Ivonne Wierink / Fotolia
relieved, with no side effects, by a new product based on
medicinal plants and dietary supplements that was developed at the
University of Montreal's Faculty of Veterinary Medicine. "While
acupuncture and electrical stimulation are two approaches that have been
shown to have positive effects on dogs, until now a few studies have
investigated a plant-based approach to therapy," explained Professor
Éric Troncy, senior author of the study. His findings were published in
Research in Veterinary Science.
Troncy and his team worked with 32 dogs (and their owners!) who had
been diagnosed with arthritis by X-ray and orthopaedic exam, and who all
weighed more than 20 kilograms. By drawing on existing rodent studies
and working with Pierre Haddad of the university's Department of
Pharmacology, Troncy developed two formulas for his trial. These
formulas are not currently commercially available.
The first formula, composed of curcumin, devil's claw, black current, Indian frankincense (Salai), willow bark, pineapple bromelaine and camomile, was developed to treat arthritis-induced inflammation. The second included the same ingredients, plus dietary supplements such as omega 3, chondroitin sulfate and glutamine, and was formulated in the hope that it would promote the regeneration of articulations.
Half the dogs received the first formula for four weeks and then the second formula for another four weeks. The other half, acting as the control, received a placebo. The outcomes were tested using three methods. Firstly, the dogs were filmed as they walked at a consistent speed over a special platform that captures the strength of each paw. Secondly, a special electronic collar recorded the dogs' daily activities. And finally, the owners were asked to provide their own evaluations of their dog's behaviour.
The researchers were able to identify an improvement by the fourth week of the trial. "After the eight week course, on average, the strength of the dogs receiving treatment had improved to the equivalent of a kilo of extra strength per paw, which is moreover. None of these dogs saw their health decline, unlike 35.8% of the dogs who were given the placebo," said Maxim Moreau, who was first author of the study.
The improvements were also reflected in the dogs' daily lives. The collars revealed that the dogs receiving treatment maintained their physical activity, and in fact the group average increased from six hours of daily activity to eight. Meanwhile, the dogs receiving the placebo were progressively less active. "In some cases, we recorded the dogs to ensure that the collar was recording actual physical activity rather than movements such as scratching," Troncy explained.
Nonetheless, the ratings from the owners were more mixed. "This third evaluation was more subjective and the contrast between the test group and the control group less stark," Troncy said. "We suspect that the owner may have forgotten what the animal's behaviour was like before it developed arthritis."
The findings raise the possibility of offering a new form of treatment to human beings. "The model of evaluation that we have used is the best for predicting the efficacy of anti-arthritis treatments. We can therefore consider that clinical trials on humans would have a good chance of having positive outcomes," Troncy said.
About this study: This study was funded in part by a grant from ArthroLab Inc., an ongoing New Opportunities Fund grant (#9483) and a Leader Opportunity Fund grant (#24601) from the Canada Foundation for Innovation for the pain/function equipment, a Discovery Grant (#327158-2008; #441651-2013) from the Natural Sciences and Engineering Research Council of Canada for the bio-analyses and salaries, and by the Osteoarthritis Chair of the University of Montreal Hospital Centre, Université de Montréal. Maxim Moreau received a doctoral scholarship from the Canadian Institutes of Health Research (TGF-53914) -- Strategic Training Initiative in Health Research program (MENTOR) and a doctoral scholarship from the Fonds de recherche du Québec-Santé.
The first formula, composed of curcumin, devil's claw, black current, Indian frankincense (Salai), willow bark, pineapple bromelaine and camomile, was developed to treat arthritis-induced inflammation. The second included the same ingredients, plus dietary supplements such as omega 3, chondroitin sulfate and glutamine, and was formulated in the hope that it would promote the regeneration of articulations.
Half the dogs received the first formula for four weeks and then the second formula for another four weeks. The other half, acting as the control, received a placebo. The outcomes were tested using three methods. Firstly, the dogs were filmed as they walked at a consistent speed over a special platform that captures the strength of each paw. Secondly, a special electronic collar recorded the dogs' daily activities. And finally, the owners were asked to provide their own evaluations of their dog's behaviour.
The researchers were able to identify an improvement by the fourth week of the trial. "After the eight week course, on average, the strength of the dogs receiving treatment had improved to the equivalent of a kilo of extra strength per paw, which is moreover. None of these dogs saw their health decline, unlike 35.8% of the dogs who were given the placebo," said Maxim Moreau, who was first author of the study.
The improvements were also reflected in the dogs' daily lives. The collars revealed that the dogs receiving treatment maintained their physical activity, and in fact the group average increased from six hours of daily activity to eight. Meanwhile, the dogs receiving the placebo were progressively less active. "In some cases, we recorded the dogs to ensure that the collar was recording actual physical activity rather than movements such as scratching," Troncy explained.
Nonetheless, the ratings from the owners were more mixed. "This third evaluation was more subjective and the contrast between the test group and the control group less stark," Troncy said. "We suspect that the owner may have forgotten what the animal's behaviour was like before it developed arthritis."
The findings raise the possibility of offering a new form of treatment to human beings. "The model of evaluation that we have used is the best for predicting the efficacy of anti-arthritis treatments. We can therefore consider that clinical trials on humans would have a good chance of having positive outcomes," Troncy said.
About this study: This study was funded in part by a grant from ArthroLab Inc., an ongoing New Opportunities Fund grant (#9483) and a Leader Opportunity Fund grant (#24601) from the Canada Foundation for Innovation for the pain/function equipment, a Discovery Grant (#327158-2008; #441651-2013) from the Natural Sciences and Engineering Research Council of Canada for the bio-analyses and salaries, and by the Osteoarthritis Chair of the University of Montreal Hospital Centre, Université de Montréal. Maxim Moreau received a doctoral scholarship from the Canadian Institutes of Health Research (TGF-53914) -- Strategic Training Initiative in Health Research program (MENTOR) and a doctoral scholarship from the Fonds de recherche du Québec-Santé.
Story Source:
The above story is based on materials provided by Universite de Montreal. Note: Materials may be edited for content and length.
The above story is based on materials provided by Universite de Montreal. Note: Materials may be edited for content and length.
Journal Reference:
Cite This Page:- Maxim Moreau, Bertrand Lussier, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Christian Bédard, Dominique Gauvin, Eric Troncy. A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: A randomized placebo-controlled trial. Research in Veterinary Science, 2014; DOI: 10.1016/j.rvsc.2014.09.011
Universite
de Montreal. "New natural supplement relieves canine arthritis."
ScienceDaily. ScienceDaily, 10 November 2014.
<www.sciencedaily.com/releases/2014/11/141110082225.htm>.
