Comparison Of Cimicifuga foetida extract and different hormone therapies regarding in causing breast pain in early postmenopausal women.

Gynecol Endocrinol. 2018 Oct 16:1-5. doi: 10.1080/09513590.2018.1505845. [Epub ahead of print] Wang YP1, Ma D2, Cheng XT3, Zhang SJ2, Xue W1, Deng Y1, Wang YF1, Sun AJ1. Author information 1 a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China. 2 b Faculty of Nursing , Peking Union Medical College Hospital , Beijing , China. 3 c Department of Obstetrics and Gynecology , Shenyang Women's and Children's hospital , Liaoning , China. Abstract This study aimed to compare the influence between Cimicifuga foetida extract and different hormone therapies on breast pain in early postmenopausal women. A prospective, randomized, controlled clinical trial was conducted among 96 early postmenopausal women. Participants were randomly assigned to three groups: group A received 1 mg/day estradiol valerate plus 4 mg/day medroxyprogesterone acetate on days 19-30; group B received 1 mg/day estradiol valerate plus 100 mg/day micronized progesterone on days 19-30; group C received C. foetida extract, 1talet (contains 33.3 mg extract), t.i.d. Breast pain diary and numerical rating scale was used to access the breast pain. For 6 months' treatment, the total incidence of breast pain in group A and B was significantly higher than that in group C (p < .05). The duration (day) of breast pain in each month decreased over time in group A and B while it was continuously low and without significant change in group C (p > .05). The intensity of breast pain was mild in most participants and did not differ among three groups (p > .05). During treatment of early postmenopausal women with C. foetida extract for 6 months, the incidence and duration of breast pain were lower than upon treatment with E2 plus cyclic MPA or m-P and did not change over time. KEYWORDS: Cimicifuga foetida; Early menopause; breast pain; menopausal hormone therapy PMID: 30324837 DOI: 10.1080/09513590.2018.1505845