Thursday, 28 September 2017

New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera C.A. Smith.

Chem Biodivers. 2017 Sep 6. doi: 10.1002/cbdv.201700260. [Epub ahead of print] Simo LM1,2, Noté OP1,2, Mbing JN2, Aouazou SA1, Guillaume D3, Muller CD1, Pegnyemb DE2, Lobstein A1. Author information 1 Laboratoire d'Innovation Thérapeutique, UMR 7200, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, F-67401, Illkirch Cedex, France. 2 Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé I, BP 812, Yaoundé, Cameroun. 3 Laboratoire de Chimie Thérapeutique, UMR7312, Université de Reims, 51 rue Cognacq-Jay, 51100, Reims, France. Abstract As part of our search of new bioactive saponins from Cameroonian medicinal plants, two new oleanane-type saponins, named gummiferaosides D-E (1-2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D and 2D NMR (1 H-, 13 C-NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY and HMBC) and HRESIMS studies, and by chemical evidence. The apoptotic effect of saponins 1-3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1-3 induced apoptosis of human epidermoid cancer cell (A431) in a dose-dependent manner. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. KEYWORDS: Albizia gummifera ; Mimosaceae; Triterpenoid saponins; apoptosis of human epidermoid cancer cell A431 PMID: 28877411 DOI: 10.1002/cbdv.201700260