The genus Psiadia: Review of traditional uses, phytochemistry and pharmacology

Journal of Ethnopharmacology Volume 210, 10 January 2018, Pages 48-68 Mahadeo K1, Grondin I2, Kodja H3, Soulange Govinden J4, Jhaumeer Laulloo S5, Frederich M6, Gauvin-Bialecki A7. https://doi.org/10.1016/j.jep.2017.08.023 1 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de la Réunion, 15 Avenue René Cassin, BP 7151, St Denis Messag Cedex 9, La Réunion 97 715, France. Electronic address: keshika.mahadeo@univ-reunion.fr. 2 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de la Réunion, 15 Avenue René Cassin, BP 7151, St Denis Messag Cedex 9, La Réunion 97 715, France. Electronic address: isabelle.grondin@univ-reunion.fr. 3 UMR Qualisud, Université de La Réunion, BP 7151, 15 Avenue René Cassin, 97744 Saint-Denis Cedex 09, La Réunion, France. Electronic address: hippolyte.kodja@univ-reunion.fr. 4 Department of Agriculture and Food Science, Faculty of Agriculture, The University of Mauritius, Mauritius. Electronic address: joyces@uom.ac.mu. 5 Department of Chemistry, Faculty of Science, The University of Mauritius, Mauritius. Electronic address: sabina@uom.ac.mu. 6 Université de Liège, Département de Pharmacie, Centre Interfacultaire de Recherche sur le Médicament (CIRM), Laboratoire de Pharmacognosie, Campus du Sart-Tilman, Quartier Hôpital, Avenue Hippocrate, 15 B36 4000 Liège, Belgium. Electronic address: M.Frederich@ulg.ac.be. 7 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de la Réunion, 15 Avenue René Cassin, BP 7151, St Denis Messag Cedex 9, La Réunion 97 715, France. Electronic address: anne.bialecki@univ-reunion.fr. Abstract Ethnopharmacological relevance The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae family and includes more than 60 species. This genus grows in tropical and subtropical regions, being especially well represented in Madagascar and the Mascarene Islands (La Réunion, Mauritius and Rodrigues). Several Psiadia species have been used traditionally for their medicinal properties in Africa and the Mascarene Islands. Based on traditional knowledge, various phytochemical and pharmacological studies have been conducted. However there are no recent papers that provide an overview of the medicinal potential of Psiadia species. Therefore, the aim of this review is to provide a comprehensive summary of the botany, phytochemistry and pharmacology of Psiadia and to highlight the gaps in our knowledge for future research opportunities. Materials and methods The available information on traditional uses, phytochemistry and biological activities of the genus Psiadia was collected from scientific databases through a search using the keyword ‘Psiadia’ in ‘Google Scholar’, ‘Pubmed’, ‘Sciencedirect’, ‘SpringerLink’, ‘Web of Science’, ‘Wiley’ and ‘Scifinder’. Additionally, published books and unpublished Ph.D. and MSc. dissertations were consulted for botanical information and chemical composition. Results Historically, species of the genus Psiadia have been used to treat a wide range of ailments including abdominal pains, colds, fevers, bronchitis, asthma, rheumatoid arthritis, skin infections and liver disorders among others. Phytochemical works led to the isolation of flavonoids, phenylpropanoids, coumarins and terpenoids. Furthermore, phytochemical compositions of the essential oils of some species have been evaluated. Crude extracts, essential oils and isolated molecules showed in vitro pharmacological activities, such as antimicrobial, anti-viral, anti-inflammatory, antiplasmodial and antileishmanial activities. Crude extracts of Psiadia dentata and Psiadia arguta have specifically been found to be potentially useful for inhibition of growth of Plasmodium falciparum. However, pharmacological data on this particular genus is quite limited. Further research is necessary to determine the active compounds and the underlying mechanisms. Graphical abstract fx1 Download high-res image (101KB)Download full-size image Keywords Psiadia Terpenoids Flavonoids Antiplasmodial Antimicrobial