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Thursday, 26 April 2018

Effect of oral ginger on prevention of nausea and vomiting after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial.

Electron Physician. 2018 Feb 25;10(2):6354-6362. doi: 10.19082/6354. eCollection 2018 Feb. Bameshki A1, Namaiee MH2, Jangjoo A3, Dadgarmoghaddam M4, Ghalibaf MHE5, Ghorbanzadeh A6, Sheybani S7. Author information 1 M.D., Anesthesiologist, Associate Professor, Department of Anesthesiology, Faculty of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran. 2 M.D., Resident of Anesthesiology, Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran. 3 M.D., Surgeon, Associate Professor, Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 4 M.D., Community Medicine Specialist, Assistant Professor, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 5 B.Sc., Anesthetist Nurse, Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran. 6 Medical Student, Mashhad University of Medical Sciences, Mashhad, Iran. 7 M.D., Cardiac Anesthesiologist, Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Abstract Background: Postoperative nausea and vomiting (PONV) are among the most frequent complications following laparoscopic cholecystectomy. Recently, some studies have shown ginger, as an herbal medicine, to be effective and safe in PONV prevention; however, there is no evidence of its efficacy in the Iranian population. Objective: The aim of this study was to determine the effect of oral ginger on PONV prevention after laparoscopic cholecystectomy. Methods: This double-blind, randomized, placebo-controlled clinical trial was performed on women who were undergoing laparoscopic cholecystectomy in Imam Raza Hospital, Mashhad, Iran between April and November, 2016. Patients were divided randomly into two groups of G) intervention group (n=75, received 2 capsules containing 250 mg ginger) and P) placebo group (n=75, received 2 placebo capsules) one hour before surgery. Nausea severity and vomiting frequency were evaluated at 2, 4, 6, and 12 hours after the operation. Data analysis was done by SPSS version 16.0 software with Chi-square test, Independent-sample-t-test, repeated measure ANOVA and Mann-Whitney U test. Results: The two groups were homogenous in terms of age, gender and surgery duration. The severity of nausea was lower in the ginger group at the 2, 4, 6, and 12 hours after the operation; however, these differences were statically significant only at 2 (p=0.034) and 12 hours (p=0.043). Although the incidence of vomiting was higher in the placebo group in the 2nd and 12th hours after surgery, the number of vomiting episodes in 2, 4, 6 and 12 hours after surgery was statistically similar in the two groups (p>0.05). The nausea severity was significantly changed during 12 hours of study in both groups (p=0.001), however the nausea severity was always lower in the ginger group (p=0.078). Conclusion: This study demonstrated that 500mg oral ginger one hour before surgery in women who were undergoing laparoscopic cholecystectomy is effective in decreasing severity of PONV. Trial registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2016122222218N2. Funding: The study was financially supported by Deputy of Research of Mashhad University of Medical Sciences. KEYWORDS: Cholecystectomy; Ginger; Laparoscopic; Nausea; Postoperative Nausea and Vomiting; Vomiting PMID: 29629059 PMCID: PMC5878030 DOI: 10.19082/6354 Free PMC Article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878030/

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