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Thursday, 19 April 2018

Potential of Bryophyllum pinnatum as a Detrusor Relaxant: An in Vitro Exploratory Study(Article)

Planta MedicaVolume 83, Issue 16, 1 November 2017, Pages 1274-1280 Bachmann, S.a, Betschart, C.b, Gerber, J.c, Fürer, K.a, Mennet, M.d, Hamburger, M.c, Potterat, O.c, Von Mandach, U.a, Simões-Wüst, A.P.aEmail Author View Correspondence (jump link) aDepartment of Obstetrics, University Hospital of Zurich, Schmelzbergstrasse 12/PF 125, Path G 51a, Zurich, Switzerland bDepartment of Gynaecology, University Hospital Zurich, Switzerland cDivision of Pharmaceutical Biology, University of Basel, Switzerland View additional affiliations Abstract View references (25) An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum. © Georg Thieme Verlag KG Stuttgart.New York. Author keywords Bryophyllum pinnatumbufadienolidesCrassulaceaeflavonoid aglyconsflavonoidsKalanchoe pinnataoveractive bladder Indexed keywords EMTREE drug terms: aglyconebufadienolideflavonoidpotassium chloridespasmolytic agentbufadienolidebufadienolide derivativeflavonoidplant extract EMTREE medical terms: animal tissueArticleBryophyllum pinnatumconcentration responsecontrolled studydetrusor muscledrug effectdrug targetingexploratory researchin vitro studymedicinal plantmuscle contractionmuscle strengthnonhumanoveractive bladderpigplant leafanimalchemistrydrug effectsfemaleKalanchoemalemuscle relaxationoveractive bladder MeSH: AnimalsBufanolidesFemaleFlavonoidsIn Vitro TechniquesKalanchoeMaleMuscle RelaxationPlant ExtractsSwineUrinary Bladder, Overactive Chemicals and CAS Registry Numbers: bufadienolide, 29565-35-3; potassium chloride, 7447-40-7; bufadienolide; Bufanolides; Flavonoids; Plant Extracts Manufacturers: Drug manufacturer: Sigma Aldrich ISSN: 00320943 CODEN: PLMEA Source Type: Journal Original language: English DOI: 10.1055/s-0043-109097 PubMed ID: 28437806 Document Type: Article Publisher: Georg Thieme Verlag References (25) View in search results format All 1 Haylen, B.T., De Ridder, D., Freeman, R.M., Swift, S.E., Berghmans, B., Lee, J., Monga, A., (...), Schaer, G.N. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction (2010) International Urogynecology Journal, 21 (1), pp. 5-26. Cited 760 times. http://www.springer.com/medicine/gynecology/journal/192 doi: 10.1007/s00192-009-0976-9 View at Publisher 2 Milsom, I., Coyne, K.S., Nicholson, S., Kvasz, M., Chen, C.-I., Wein, A.J. Global prevalence and economic burden of urgency urinary incontinence: A systematic review (2014) European Urology, 65 (1), pp. 79-95. Cited 95 times. doi: 10.1016/j.eururo.2013.08.031 View at Publisher 3 Nambiar, A., Lucas, M. Chapter 4: Guidelines for the diagnosis and treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) (2014) Neurourology and Urodynamics, 33 (SUPPL.3), pp. S21-S25. Cited 26 times. www.interscience.wiley.com/jpages/0733-2467 doi: 10.1002/nau.22631 View at Publisher 4 Gormley, E.A., Lightner, D.J., Faraday, M., Vasavada, S.P. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment (2015) Journal of Urology, Part S 193 (5), pp. 1572-1580. Cited 134 times. http://www.sciencedirect.com/science?_ob=Publication doi: 10.1016/j.juro.2015.01.087 View at Publisher 5 Slavin, S.L., Rogers, R.G., Komesu, Y., Omotosho, T., Hammil, S., Lewis, C., Sapien, R. Complementary and alternative medicine (CAM) use in women with pelvic floor disorders: A cohort study (2010) International Urogynecology Journal, 21 (4), pp. 431-437. Cited 5 times. http://www.springer.com/medicine/gynecology/journal/192 doi: 10.1007/s00192-009-1058-8 View at Publisher 6 Fürer, K., Simões-Wüst, A.P., Von Mandach, U., Hamburger, M., Potterat, O. Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy (2016) Planta Medica, 82 (11-12), pp. 930-941. Cited 6 times. http://www.thieme-connect.com/ejournals/toc/plantamedica doi: 10.1055/s-0042-106727 View at Publisher 7 Kienle, G.S., Albonico, H.U., Baars, E., Hamre, H.J., Zimmermann, P., Kiene, H. Anthroposophic medicine: An integrative medical system originating in Europe (2013) Glob Adv Health Med, 2, pp. 20-31. Cited 31 times. 8 Fürer, K., Simões-Wüst, A.P., Winkler, A., Amsler, N., Schnelle, M., Von Mandach, U. The Application of Bryophyllum pinnatum Preparations in Obstetrics and Gynaecology - A Multicenter, Prospective Observational Study (2015) Complementary Medicine Research, 22 (4), pp. 231-236. Cited 3 times. http://www.karger.com/Journal/Home/224242 doi: 10.1159/000437154 View at Publisher 9 Betschart, C., Von Mandach, U., Seifert, B., Scheiner, D., Perucchini, D., Fink, D., Geissbühler, V. Randomized, double-blind placebo-controlled trial with Bryophyllum pinnatum versus placebo for the treatment of overactive bladder in postmenopausal women (2013) Phytomedicine, 20 (3-4), pp. 351-358. Cited 12 times. doi: 10.1016/j.phymed.2012.10.007 View at Publisher 10 Fürer, K., Raith, M., Brenneisen, R., Mennet, M., Simões-Wüst, A.P., Von Mandach, U., Hamburger, M., (...), Potterat, O. Two new flavonol glycosides and a metabolite profile of bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology (2013) Planta Medica, 79 (16), pp. 1565-1571. Cited 16 times. doi: 10.1055/s-0033-1350808 View at Publisher 11 Oufir, M., Seiler, C., Gerodetti, M., Gerber, J., Fürer, K., Mennet-von Eiff, M., Elsas, S.-M., (...), Potterat, O. Quantification of Bufadienolides in Bryophyllum pinnatum Leaves and Manufactured Products by UHPLC-ESIMS/MS (2015) Planta Medica, 81 (12-13), pp. 1190-1197. Cited 5 times. http://www.thieme-connect.com/ejournals/toc/plantamedica doi: 10.1055/s-0035-1546126 View at Publisher 12 Wagner, H., Lotter, H., Fischer, M. (1986) Helvetica Chimica Acta, 69 (2), pp. 359-367. Cited 29 times. doi: 10.1002/hlca.19860690215 13 McKenzie, R.A., Franke, F.P., Dunster, P.J. The toxicity to cattle and bufadienolide content of six Bryophyllum species. (1987) Australian veterinary journal, 64 (10), pp. 298-301. Cited 33 times. doi: 10.1111/j.1751-0813.1987.tb07330.x View at Publisher 14 Benavente-García, O., Castillo, J. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity (2008) Journal of Agricultural and Food Chemistry, 56 (15), pp. 6185-6205. Cited 535 times. doi: 10.1021/jf8006568 View at Publisher 15 Gwehenberger, B., Rist, L., Huch, R., Von Mandach, U. Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility (2004) European Journal of Obstetrics Gynecology and Reproductive Biology, 113 (2), pp. 164-171. Cited 25 times. doi: 10.1016/S0301-2115(03)00370-1 View at Publisher 16 Wächter, R., Brenneisen, R., Hamburger, M., Mennet, M., Schnelle, M., Worel, A.M., Simões-Wüst, A.P., (...), Von Mandach, U. Leaf press juice from Bryophyllum pinnatum (Lamarck) Oken induces myometrial relaxation (2011) Phytomedicine, 19 (1), pp. 74-82. Cited 17 times. doi: 10.1016/j.phymed.2011.06.032 View at Publisher 17 Simões-Wüst, A.P., Grãos, M., Duarte, C.B., Brenneisen, R., Hamburger, M., Mennet, M., Ramos, M.H., (...), von Mandach, U. Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells (2010) Phytomedicine, 17 (12), pp. 980-986. Cited 16 times. doi: 10.1016/j.phymed.2010.03.005 View at Publisher 18 Schuler, V., Suter, K., Fürer, K., Eberli, D., Horst, M., Betschart, C., Brenneisen, R., (...), Von Mandach, U. Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips - A pharmacological study towards a new treatment option of overactive bladder (2012) Phytomedicine, 19 (10), pp. 947-951. Cited 15 times. doi: 10.1016/j.phymed.2012.05.003 View at Publisher 19 Fürer, K., Eberli, D., Betschart, C., Brenneisen, R., De Mieri, M., Hamburger, M., Mennet-Von Eiff, M., (...), Von Mandach, U. Inhibition of porcine detrusor contractility by the flavonoid fraction of Bryophyllum pinnatum - A potential phytotherapeutic drug for the treatment of the overactive bladder syndrome (2015) Phytomedicine, 22 (1), pp. 158-164. Cited 5 times. www.urbanfischer.de/journals/phytomed doi: 10.1016/j.phymed.2014.11.009 View at Publisher 20 Rodriguez-Mateos, A., Vauzour, D., Krueger, C.G., Shanmuganayagam, D., Reed, J., Calani, L., Mena, P., (...), Crozier, A. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update (2014) Archives of Toxicology, 88 (10), pp. 1803-1853. Cited 149 times. link.springer.de/link/service/journals/00204/index.htm doi: 10.1007/s00204-014-1330-7 View at Publisher 21 Badawi, J.K., Uecelehan, H., Hatzinger, M., Michel, M.S., Haferkamp, A., Bross, S. Relaxant effects of β-adrenergic agonists on porcine and human detrusor muscle (2005) Acta Physiologica Scandinavica, 185 (2), pp. 151-159. Cited 18 times. doi: 10.1111/j.1365-201X.2005.01474.x View at Publisher 22 Dagostino, G., Maria Condino, A., Calvi, P. Involvement of β3-adrenoceptors in the inhibitory control of cholinergic activity in human bladder: Direct evidence by [3H]-acetylcholine release experiments in the isolated detrusor (2015) European Journal of Pharmacology, 758, pp. 115-122. Cited 21 times. www.elsevier.com/locate/ejphar doi: 10.1016/j.ejphar.2015.03.074 View at Publisher 23 Gründemann, C., Diegel, C., Sauer, B., Garcia-Käufer, M., Huber, R. Immunomodulatory effects of preparations from Anthroposophical Medicine for parenteral use (2015) BMC Complementary and Alternative Medicine, 15 (1), art. no. 219. Cited 3 times. http://www.biomedcentral.com/bmccomplementalternmed/ doi: 10.1186/s12906-015-0757-6 View at Publisher 24 Wu, S.-H., Bau, D.-T., Hsiao, Y.-T., Lu, K.-W., Hsia, T.-C., Lien, J.-C., Ko, Y.-C., (...), Chung, J.-G. Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo (2017) Environmental Toxicology, 32 (4), pp. 1305-1317. Cited 8 times. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-7278 doi: 10.1002/tox.22325 View at Publisher 25 Rather, M.A., Bhat, B.A., Qurishi, M.A. Multicomponent phytotherapeutic approach gaining momentum: Is the "one drug to fit all" model breaking down? (2013) Phytomedicine, 21 (1), pp. 1-14. Cited 40 times. doi: 10.1016/j.phymed.2013.07.015 View at Publisher Simões-Wüst, A.P.; Department of Obstetrics, University Hospital of Zurich, Schmelzbergstrasse 12/PF 125, Path G 51a, Zurich, Switzerland; email:anapaula.simoes-wuest@usz.ch © Copyright 2018 Elsevier B.V., All rights reserved.

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