Monday, 17 September 2018

Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia(Article)

Phytotherapy Research Volume 32, Issue 8, August 2018, Pages 1636-1641 McGill, C.M.a, Tomco, P.L.a, Ondrasik, R.M.b, Belknap, K.C.c, Dwyer, G.K.a, Quinlan, D.J.a, Kircher, T.A.a, Andam, C.P.c, Brown, T.J.b, Claxton, D.F.b, Barth, B.M.b,cEmail Author View Correspondence (jump link) aDepartment of Chemistry, University of Alaska Anchorage, Anchorage, AK 99508, United States bDepartment of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, United States cDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, United States Abstract View references (18) Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is one of the more common pediatric malignancies in addition to occurring with high incidence in the aging population. Unfortunately, these patient groups are quite sensitive to toxicity from chemotherapy. Northern Labrador tea, or Rhododendron tomentosum Harmaja (a.k.a. Ledum palustre subsp. decumbens) or “tundra tea,” is a noteworthy medicinal plant used by indigenous peoples in Alaska, Canada, and Greenland to treat a diversity of ailments. However, laboratory investigations of Northern Labrador tea, and other Labrador tea family members, as botanical sources for anticancer compounds have been limited. Utilizing an AML cell line in both in vitro and in vivo studies, as well as in vitro studies using primary human AML patient samples, this study demonstrated for the first time that Northern Labrador tea extracts can exert anti-AML activity and that this may be attributed to ursolic acid as a constituent component. Therefore, this medicinal herb holds the potential to serve as a source for further drug discovery efforts to isolate novel anti-AML compounds. Copyright © 2018 John Wiley & Sons, Ltd. Author keywords acute myeloid leukemiaNorthern Labrador teaRhododendron tomentosumursolic acid Funding details Funding number Funding sponsor Acronym Funding opportunities K22‐CA190674 Foundation for the National Institutes of Health FNIH See opportunities by FNIH Funding text We would like to thank Dr. Steffi Ickert‐Bond, curator of the herbarium at the University of Alaska Museum of the North located at the University of Alaska Fairbanks, for identifying specimens of Northern Labrador tea. This study was funded in part by the National Cancer Institute of the National Institutes for Health under award number K22‐CA190674 (B. M. B.), the University of New Hampshire Collaborative Research Excellence Initiative, the Penn State University Kiesendahl Family Endowed Leukemia Research Fund, the Kenneth Noel Memorial Fund, and PA Tobacco Settlement funds. In addition, funding was provided by the University of Alaska Anchorage Office of Undergraduate Research and Scholarship—Alaska Heart Institute Fellowship. ISSN: 0951418X CODEN: PHYRE Source Type: Journal Original language: English DOI: 10.1002/ptr.6091 Document Type: Article Publisher: John Wiley and Sons Ltd References (18) View in search results format All Export Print E-mail Save to PDF Create bibliography 1 Arber, D.A., Orazi, A., Hasserjian, R., Thiele, J., Borowitz, M.J., Le Beau, M.M., Bloomfield, C.D., (...), Vardiman, J.W. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia (2016) Blood, 127 (20), pp. 2391-2405. Cited 1142 times. doi: 10.1182/blood-2016-03-643544 View at Publisher 2 Barth, B.M., Brown, T.J., Adams, M.T., Garcia, A.M., Fisher, L.N., Fritz, J.L., Claxton, D.F. 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