Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2843. doi: 10.3390/ijms19092843. Salehi B1,2, Albayrak S3, Antolak H4, Kręgiel D5, Pawlikowska E6, Sharifi-Rad M7, Uprety Y8, Tsouh Fokou PV9, Yousef Z10, Amiruddin Zakaria Z11,12, Varoni EM13,14, Sharopov F15, Martins N16,17, Iriti M18,19, Sharifi-Rad J20,21. Author information 1 Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran. bahar.salehi007@gmail.com. 2 Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran. bahar.salehi007@gmail.com. 3 Department of Biology, Science Faculty, Erciyes University, Kayseri 38039, Turkey. salbayrak@erciyes.edu.tr. 4 Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Science, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland. hubert.antolak@gmail.com. 5 Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Science, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland. dorota.kregiel@p.lodz.pl. 6 Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Science, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland. ewelina.pawlikowska@dokt.p.lodz.pl. 7 Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663-335, Iran. mehdi_sharifirad@yahoo.com. 8 Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, P.O. Box 1030 Kirtipur, Kathmandu, Nepal. yadavuprety@gmail.com. 9 Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box 812 Yaounde, Cameroon. tsouh80@yahoo.fr. 10 Department of Botany, Lahore College for Women University, Jail Road Lahore 54000, Pakistan. mussabuswaeshal@hotmail.com. 11 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. dr_zaz@yahoo.com. 12 Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3 Building, Universiti Teknologi MARA, Puncak Alam 42300, Malaysia. dr_zaz@yahoo.com. 13 Department of Biomedical, Surgical and Dental Sciences, Milan State University, via Beldiletto 1/3, 20100 Milan, Italy. elena.varoni@unimi.it. 14 National Interuniversity Consortium of Materials Science and Technology, via G. Giusti 9, 50121 Firenze, Italy. elena.varoni@unimi.it. 15 Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan. shfarukh@mail.ru. 16 Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. ncmartins@med.up.pt. 17 Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal. ncmartins@med.up.pt. 18 National Interuniversity Consortium of Materials Science and Technology, via G. Giusti 9, 50121 Firenze, Italy. marcello.iriti@unimi.it. 19 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy. marcello.iriti@unimi.it. 20 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran. javad.sharifirad@gmail.com. 21 Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, 599 Portage Avenue, Winnipeg, MB R3B 2G3, Canada. javad.sharifirad@gmail.com. Abstract Aloe genus plants, distributed in Old World, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal, and skin care properties. Among the well-investigated Aloe species are A. arborescens, A. barbadensis, A. ferox, and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases via the modulation of biochemical and molecular pathways, besides being a rich source of valuable phytochemicals. In the present review, we summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants. These data will be helpful to provide future directions for the industrial and medicinal use of Aloe plants. KEYWORDS: Aloe species; aloe emodin; aloesin; aloin; aloinoside; isovitexin; plicataloside PMID: 30235891 DOI: 10.3390/ijms19092843 Free full text