used treatments for breast cancer are known to induce premature
menopause. These include chemotherapy and endocrine (hormone) therapy
such as tamoxifen. Such treatments cause suppression of ovarian
function. In post-menopausal women, the use of other hormonal drugs—eg,
aromatase inhibitors—leads to decreased circulating oestrogen
concentrations, that can, in turn, also induce menopausal symptoms,
including hot flashes, vaginal dryness, night sweats, depression,
fatigue, and altered sexual function.