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Article: Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ... Cited in 1 publication: Article: Ethnobotanical study, antifungal activity, phytochemical screening and total phenolic cont... Bachir Benarba J Intercult Ethnopharmacol 01/2014 3(4):150-154. View Article: Ethnomedicines used in Trinidad and Tobago for reproductive problems. Cited in 1 publication: Article: Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum. Patricio Rojas-Silva, Rocky Graziose, Brian Vesely... Pharmaceutical Biology 10/2013 Pharm Biol. 2014 Mar;52(3):398-401. doi: 10.3109/13880209.2013.837077. Epub 2013 Oct 23. Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum.   Rojas-Silva P1, Graziose R, Vesely B, Poulev A, Mbeunkui F, Grace MH, Kyle DE, Lila MA, Raskin I. Author information Abstract CONTEXT: Eryngium foetidum L. (Apiaceae) is a traditional herb that has been used for numerous medicinal applications, including as a treatment for parasitic infections, especially in the Neotropics from where it originates. OBJECTIVE: This study evaluates the in vitro leishmanicidal and cytotoxicity activities of isolated compounds based on a bioassay-guided fractionation approach. MATERIALS AND METHODS: Defatted aerial parts of E. foetidum were subjected to extraction with methanol followed by partitioning with n-hexane, ethyl acetate and 50% methanol. Then, the first two fractions were subsequently fractionated by column chromatography and HPLC. Compound identity was confirmed by mass spectrometry and NMR spectroscopy. Leishmania tarentolae (promastigotes) and L. donovani (amastigotes) were used as testing parasites. L6 rat myoblasts were used for cytotoxicity. All extracts and fractions were tested at 20 μg/mL. RESULTS: The initial methanol extract showed 20% growth inhibition of L. tarentolae. Then, the n-hexane and ethyl acetate fractions were also active showing approximately 40% growth inhibition. From these two fractions, the following compounds were isolated: lasidiol p-methoxybenzoate (1), a daucane sesquiterpene; and 4-hydroxy-1,1,5-trimethyl-2-formyl-cyclohexadien-(2,5)-[α-acetoxymethyl-cis-crotonate] (2), a terpene aldehyde ester derivative. Compound 1 inhibited the growth of both L. tarentolae and L. donovani with IC₅₀ values of 14.33 and 7.84 μM, respectively; and showed no cytotoxicity (IC₅₀ > 50 μM). Compound 2 was inactive in the L. tarentolae assay (IC₅₀ > 50 μM). DISCUSSION AND CONCLUSION: This study presented the bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species.  http://www.ncbi.nlm.nih.gov/pubmed/24147866