DOI: 10.5897/JVMAH2015.0448
ISSN: 2141-2529
Full Length Research Paper
- Abstract
- References
- How to cite this article
Urolithiasis is a common disorder of humans and animals. The surgical
intervention to correct the condition is expensive and alternative
cheaper botanical treatments should be explored. Various botanicals have
been shown in vitro not only to dissolute, but also inhibit orolith
accretions. In this study the in-vitro efficacy, anti-urolithiatic
potential and dissolution rate of aqueous and ethanol, chloroform, and
ether extracts of Moringa oliefera roots on canine uroliths was
investigated without simulation of in vivo experimentation. In the
aqueous extract an average dissolution of calcium oxalate (CaOx) was
77%. The rate of dissolution of the Calcium Oxalate (CaOx) increased
linearly. However, ethanol and chloroform extracts increased both the
rates of dissolution by weight and surface area linearly. The oral use
aqueous extracts is considered a safe measure in treating various
clinical conditions including urolithiais in humans and animals. The
dissolution rates of ortholiths in organic solvents are probably
associated with the presence of organic compounds unique to the Moringa
family. The potential of using moringha extracts may prove to be an
ethno-veterinary practice to address urolithiasis in animals.
Key words: Anti-urolithiatic, Moringa oliefera,
dissolution rate, aqueous extract, magnesium ammonium phosphate (MAP),
calcium oxalate (CaOx)
