Guillain-Barré Syndrome and Chikungunya: Description of All Cases Diagnosed during the 2014 Outbreak in the French West Indies.

Am J Trop Med Hyg. 2017 Jul 3. doi: 10.4269/ajtmh.15-0753. [Epub ahead of print]

Balavoine S1, Pircher M2, Hoen B3,4,1, Herrmann-Storck C5, Najioullah F6, Madeux B7, Signate A8, Valentino R9, Lannuzel A10,11,4, Saint Louis M12, Cassadou S13, Cabié A3,4,2, Schepers K1.

Author information

1

Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

2

Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Martinique, Martinique, France.

3

INSERM CIC1424, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

4

Faculté de Médecine Hyacinthe Bastaraud, Université des Antilles, Pointe-à-Pitre, France.

5

Laboratoire de Virologie, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

6

Laboratoire de Virologie, Centre Hospitalier Universitaire de Martinique, Martinique, France.

7

Service de Réanimation, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

8

Service de Neurologie, Centre Hospitalier Universitaire de Martinique, Martinique, France.

9

Service de Réanimation, Centre Hospitalier Universitaire de Martinique, France.

10

Institut National de la Santé et de la Recherche Médicale, U 1127, CNRS, Unité Mixte de Recherche (UMR) 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

11

Service de Neurologie, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

12

Service de Soins de Suite et Réadaptation, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.

13

Cellule d'intervention en région (Cire), Santé Publique France, Saint-Maurice, France.

Abstract

The Guillain-Barré syndrome (GBS) has been reported as a possible complication of acute chikungunya infection. The chikungunya epidemics, which occurred in Martinique and Guadeloupe in 2014, affected 308,000 people in these two islands. GBS occurred during or immediately after acute chikungunya infection in 13 patients (10 men, three women; mean age: 61 years). Median time from acute chikungunya to GBS onset was 9 days. Twelve patients were treated with intravenous polyvalent immunoglobulins, nine of whom improved within 7 days. Five of 13 patients required mechanical ventilation. Two patients with severe GBS died. At 6 months of follow-up, 7/13 achieved a good functional recovery with no or minor residual symptoms. A 2-fold increase in incidence was observed during the year of chikungunya outbreak. This study supports prior reports suggesting that GBS may be a complication of chikungunya.

PMID:

 

28722564

 

DOI:

 

10.4269/ajtmh.15-0753