Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait).

J Ethnopharmacol. 2018 Jan 30;211:235-246. doi: 10.1016/j.jep.2017.09.009. Epub 2017 Sep 14. Tümen İ1, Akkol EK2, Taştan H3, Süntar I4, Kurtca M5. Author information 1 Department of Forest Products Chemistry, Faculty of Forestry, Bartin University, 74100 Bartin, Turkey; Vocational School of Health Services, Bartin University, 74100 Bartin, Turkey. 2 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey. Electronic address: esrak@gazi.edu.tr. 3 Department of Biology, Faculty of Science, Gazi University, Etiler 06330, Ankara, Turkey. 4 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey. 5 Vocational School of Health Services, Bartin University, 74100 Bartin, Turkey. Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Ethnobotanical investigations have shown that the Pinus species have been used against rheumatic pain and for wound healing in Turkish folk medicine. MATERIAL AND METHODS: In this study, phytochemical composition, antioxidant, anti-inflammatory, and wound healing activities of Maritime Pine (Pinus pinaster Ait.) that is collected in Turkey are investigated. Essential oil composition and the amount of extracts (lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested. RESULTS: The essential oil from cones of P. pinaster revealed the highest activities, whereas other parts of the plant did not display any appreciable wound healing, anti-inflammatory, or antioxidant effects. α-Pinene was the main constituent of the essential oil obtained from the cones of P. pinaster. CONCLUSION: Experimental studies shown that P. pinaster's remarkable anti-inflammatory and wound healing activities support the traditional use of the plant, and suggest it could have a place in modern medicine. Copyright © 2017 Elsevier B.V. All rights reserved. KEYWORDS: Essential oil; Inflammation; Martime pine; Pinaceae; Pinus pinaster; Wound