Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial.

Format: Abstract Send to J Nutr Biochem. 2018 Jan;51:99-104. doi: 10.1016/j.jnutbio.2017.09.010. Epub 2017 Sep 28. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. Farràs M1, Fernández-Castillejo S2, Rubió L3, Arranz S4, Catalán Ú2, Subirana I5, Romero MP6, Castañer O7, Pedret A8, Blanchart G9, Muñoz-Aguayo D7, Schröder H10, Covas MI11, de la Torre R12, Motilva MJ6, Solà R2, Fitó M13. Author information 1 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN); Ph.D. Program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. 2 Research Unit on Lipids and Atherosclerosis, St. Joan de Reus University Hospital, Institut d'Investigació Sanitària Pere Virgili (IISPV), Functional Nutrition, Oxidation, and Cardiovascular Disease (NFOC-SALUT) group, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain. 3 Research Unit on Lipids and Atherosclerosis, St. Joan de Reus University Hospital, Institut d'Investigació Sanitària Pere Virgili (IISPV), Functional Nutrition, Oxidation, and Cardiovascular Disease (NFOC-SALUT) group, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain; Food Technology Department, UTPV-XaRTA, Agrotecnio Center, University of Lleida, Alcalde Rovira Roure 191, 25198 Lleida, Spain. 4 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain. 5 CIBER de Epidemiología y Salud Pública (CIBERESP); Cardiovascular Epidemiology and Genetics Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain. 6 Food Technology Department, UTPV-XaRTA, Agrotecnio Center, University of Lleida, Alcalde Rovira Roure 191, 25198 Lleida, Spain. 7 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN). 8 Research Unit on Lipids and Atherosclerosis, St. Joan de Reus University Hospital, Institut d'Investigació Sanitària Pere Virgili (IISPV), Functional Nutrition, Oxidation, and Cardiovascular Disease (NFOC-SALUT) group, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain; Eurecat-Centre Tecnològic de Nutrició i Salut (Eurecat-CTNS), Reus, Spain. 9 Cardiovascular Epidemiology and Genetics Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain. 10 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP). 11 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN); NUPROAS Handelsbolag, Nacka, Sweden. 12 CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN); Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (CEXS-UPF), Doctor Aiguader 80, 08003 Barcelona, Spain. 13 Cardiovascular Risk and Nutrition Research Group, Regicor Study Group. IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN). Electronic address: mfito@imim.es. Abstract At present, high-density lipoprotein (HDL) function is thought to be more relevant than HDL cholesterol quantity. Consumption of olive oil phenolic compounds (PCs) has beneficial effects on HDL-related markers. Enriched food with complementary antioxidants could be a suitable option to obtain additional protective effects. Our aim was to ascertain whether virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complementary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm) and (c) FVOOT (500 ppm) in a randomized, double-blind, controlled, crossover trial. A rise in HDL antioxidant compounds was observed after both functional olive oil interventions. Nevertheless, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline. In conclusion, long-term consumption of phenol-enriched olive oils induced a better HDL antioxidant content, the complementary phenol-enriched olive oil being the one which increased the main HDL antioxidant, α-tocopherol. Complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants. KEYWORDS: Cholesterol efflux; Functional virgin olive oil; HDL antioxidants; HDL fluidity; HDL functionality; Phenol PMID: 29125992 DOI: 10.1016/j.jnutbio.2017.09.010