In vitro antitoxin activity of aqueous extracts of selective medicinal herbs against Naja naja venom

Vol. 7, Issue 1 (2018) AUTHOR(S): Mani M, Revathi P, Prabhusaran N and Pramila MABSTRACT: There is increasing global health problems related to snake bites and its complications in India. In the medical practice, the only therapy for treating snake bite victims is anti-snake venom serum, but it has huge acute and chronic including late adverse reactions in humans. Thus this study was aimed to analyze the potential of selective medicinal herbs against Naja naja toxin by in vitro methods. The aqueous extracts of fruit, root, seed, bark and leaf of Emblica officinalis, Hemidesmus indicus, Tamarindus indicus, Mangifera indica and Vitex negundo were prepared respectively. Various concentrations of the extracts were used to evaluate in vitro anti toxin activity by acetylcholinesterase, protease, direct hemolysis, phospholipase and procoagulant activities. The results indicate that the root and bark extracts of H. indicus and M. indica possesses significant bioactive compounds that can neutralize the toxins of N. Naja.PAGES: 585-589 | 117 VIEWS 8 DOWNLOADSDOWNLOAD (564KB)