Journal of Ethnopharmacology
Research Paper
Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug
doi:10.1016/j.jep.2014.11.050
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Abstract
Ethnopharmacological relevance
Materials and Methods
Results
Conclusions
Graphical abstract
Keywords
- Hancornia speciosa;
- Diabetes;
- α-glucosidase;
- Glucose uptake;
- Anti-hyperglycemic
Corresponding author. Tel.: +55 31 3409 2726; fax: +55 31 3409 2695.
Volume 161, 23 February 2015, Pages 30–35
Journal of Ethnopharmacology
Research Paper
Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug
Get rights and content
Abstract
Ethnopharmacological relevance
Materials and Methods
Results
Conclusions
Graphical abstract
Keywords
Research Paper
Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug
Get rights and content
Abstract
Ethnopharmacological relevance
Materials and Methods
Results
Conclusions
Graphical abstract
Keywords
- Hancornia speciosa;
- Diabetes;
- α-glucosidase;
- Glucose uptake;
- Anti-hyperglycemic
Volume 161, 23 February 2015, Pages 30–35
The leaves of Hancornia speciosa
Gomes are traditionally used to treat diabetes in Brazil. The aim of
the study is to evaluate the potential anti-diabetic effect of Hancornia speciosa extract and derived fractions.
The leaves of Hancornia speciosa
Gomes are traditionally used to treat diabetes in Brazil. The aim of
the study is to evaluate the potential anti-diabetic effect of Hancornia speciosa extract and derived fractions.
The ethanolic extract from Hancornia speciosa
leaves and chromatographic fractions thereof were evaluated on
α-glucosidase assay, on hyperglycemic effect and glucose uptake. The
chemical composition of the extract and its most active fraction was
investigated by ESI–LC–MS.
The ethanolic extract from Hancornia speciosa
leaves and chromatographic fractions thereof were evaluated on
α-glucosidase assay, on hyperglycemic effect and glucose uptake. The
chemical composition of the extract and its most active fraction was
investigated by ESI–LC–MS.
The
ethanolic extract and derived fractions inhibited α-glucosidase in
vitro. However, only the crude extract and the dichloromethane fraction
inhibited the hyperglycemic effect induced by starch or glucose. Both
the extract and dichloromethane fraction were also able to increase
glucose uptake in adipocytes. Bornesitol, quinic acid, and chorogenic
acid were identified in the extract, along with flavonoid glycosides,
whereas the dichloromethane fraction is majorly composed by esters of
lupeol and/or α/β-amirin.
The
ethanolic extract and derived fractions inhibited α-glucosidase in
vitro. However, only the crude extract and the dichloromethane fraction
inhibited the hyperglycemic effect induced by starch or glucose. Both
the extract and dichloromethane fraction were also able to increase
glucose uptake in adipocytes. Bornesitol, quinic acid, and chorogenic
acid were identified in the extract, along with flavonoid glycosides,
whereas the dichloromethane fraction is majorly composed by esters of
lupeol and/or α/β-amirin.
Hancornia speciosa
has a potential anti-diabetic effect through a mechanism dependent on
inhibition of α-glucosidase and increase on glucose uptake. These
results give support to the use on traditional medicine of this
medicinal plant.
Hancornia speciosa
has a potential anti-diabetic effect through a mechanism dependent on
inhibition of α-glucosidase and increase on glucose uptake. These
results give support to the use on traditional medicine of this
medicinal plant.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
