Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review.

J Thromb Thrombolysis. 2017 Nov 9. doi: 10.1007/s11239-017-1580-3. [Epub ahead of print] Memariani Z1,2, Moeini R1,2, Hamedi SS3, Gorji N4,5, Mozaffarpur SA1,2. Author information 1 Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 2 School of Traditional Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 3 School of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. 4 Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. n.gorji@mubabol.ac.ir. 5 School of Traditional Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. n.gorji@mubabol.ac.ir. Abstract Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties. This study reviewed the pharmacological effects of medicinal plants mentioned in PM literature for blood clot management in light of current knowledge. Plants mentioned in PM for management of blood clot belong to 12 families in which Apiaceae, Lamiaceae and Compositae were the most repeated ones. Among the proposed plants Allium sativum, Rosmarinus officinalis, Boswellia serrata, Sesamum indicum, Matricaria chamomilla and Carthamus tinctorius have been the most researched plants in modern antithrombotic studies while for some plants such as Helichrysum stoechas, Dracocephalum kotschi, Carum carvi, Bunium persicum and Lagoecia cuminoides no evidence could be found. One of the interesting notes in clot management in PM texts was introducing the target organ for some of the recommended herbs like Carum carvi and Bunium persicum for dissolving blood clot in stomach and Commiphora mukul for thrombosed hemorrhoid. It seems review of PM recommendations can help to design future researches for antithrombotic drugs discovering with more effectiveness and safety. KEYWORDS: Antithrombotic; Herbal medicine; Persian medicine; Thrombolytic; Thrombosis PMID: 29124622 DOI: 10.1007/s11239-017-1580-3