Medicinal Plant Materials in the Treatment of Anxiety Disorders: Neurobiological Aspects. Gołyszny MJ, Obuchowicz E.

Altern Ther Health Med. 2018 Jan 15. pii: AT5645. [Epub ahead of print] Medicinal Plant Materials in the Treatment of Anxiety Disorders: Neurobiological Aspects. Gołyszny MJ, Obuchowicz E. Abstract Context • Pathological anxiety, which affects approximately one-third of the world population, is an inadequate, irrational reaction of an organism to the environment and to a potential threat. Despite advancements in pharmacotherapy for anxiety disorders, further studies are still necessary to search for new substances possessing the desired anxiolytic effects, with as few unwanted effects as possible. Objective • This study intended to examine the characteristics of medicinal plant materials that exhibit anxiolytic properties, with a special emphasis on the mechanisms of action of their active ingredients on the systems involved in the pathophysiology of anxiety. Design • The research team performed a review of the literature, searching well-known online scientific databases, including PubMed, Google Scholar, Medline, ScienceDirect, and SpringerLink. The team searched for the newest research from various regions of the world. Setting • The study was done in the Medical University of Silesia (Katowice, Poland). Results • The medicinal plant materials presented in the current article undoubtedly influence the central nervous system. Our analysis showed that their mechanism of action is very complicated and appropriately still enigmatic. Among them, V officinalis represents the most thoroughly investigated medicinal plant material that produces anxiolytic, sedative effects. However, extracts of other medicinal plants may also emerge as helpful in the treatment of fear and anxiety and in the prophylaxis of those disorders. Conclusions • The current review discusses the most recent data on medicinal plant materials that are effective as anxiolytic treatments, with special emphasis on the neurobiological mechanisms of action of their active ingredients. The research team hopes that the information may open up new directions in the search for drugs capable of enhancing the existing therapy.