Lupeol and Its Role in Chronic Diseases

Drug Discovery from Mother Nature pp 145-175 | Cite as Authors Authors and affiliations Fan-Shiu TsaiLi-Wei LinChi-Rei WuEmail author Fan-Shiu Tsai 1 Li-Wei Lin 1 Chi-Rei Wu 2Email author 1.School of Chinese Medicines for Post-BaccalaureateI-Shou UniversityKaohsiungTaiwan 2.Department of Chinese Pharmaceutical Sciences and Chinese Medicine ResourcesChina Medical UniversityTaichungTaiwan Chapter First Online: 23 October 2016 2 Citations 2 Mentions 963 Downloads Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 929) Abstract Lupeol belongs to pentacyclic lupane-type triterpenes and exhibits in edible vegetables, fruits and many plants. Many researches indicated that lupeol possesses many beneficial pharmacological activities including antioxidant, anti-inflammatory, anti-hyperglycemic, anti-dyslipidemic and anti-mutagenic effects. From various disease-targeted animal models, these reports indicated that lupeol has anti-diabetic, anti-asthma, anti-arthritic, cardioprotective, hepatoprotective, nephroprotective, neuroprotective and anticancer efficiency under various routes of administration such as topical, oral, subcutaneous, intraperitoneal and intravenous. It is worth mentioning that clinical trials of lupeol were performed to treat canine oral malignant melanoma and human moderate skin acne in Japan and Korea. The detailed mechanism of anti-inflammatory, anti-diabetic, hepatoprotective and anticancer activities was further reviewed from published papers. These evidence indicate that lupeol is a multi-target agent to exert diverse pharmacological potency with many potential targeting proteins such as α-glucosidase, α-amylase, protein tyrosine phosphatase 1B (PTP 1B) and TCA cycle enzymes and targeting pathway such as IL-1 receptor-associated kinase-mediated toll-like receptor 4 (IRAK-TLR4), Bcl-2 family, nuclear factor kappa B (NF-kB), phosphatidylinositol-3-kinase (PI3-K)/Akt and Wnt/β-catenin signaling pathways. This review also provides suggestion that lupeol might be a valuable and potential lead compound to develop as anti-inflammatory, anti-diabetic, hepatoprotective and anticancer drugs. Keywords Lupeol Triterpene Anti-inflammatory Anti-diabetic Anticancer Hepatoprotective Cardioprotective Nephroprotective Fan-Shiu Tsai and Li-Wei Lin have equally contributed. This is a preview of subscription content, log in to check access. References 1. 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