One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial.

J Investig Clin Dent. 2018 May 2:e12334. doi: 10.1111/jicd.12334. [Epub ahead of print] Ipshita S1, Kurian IG1, Dileep P1, Kumar S2, Singh P3, Pradeep AR1. Author information 1 Department of Periodontology, Government Dental College and Research Institute, Bangalore, Karnataka, India. 2 Department of Medicine, Employee's State Insurance Postgraduate Institute of Medical Science and Research, Bangalore, Karnataka, India. 3 Department of Opthalmology, Grant Medical College and JJ Group of Hospitals, Mumbai, Maharashtra, India. Abstract AIM: Alendronate (ALN) has antiresorptive and osteostimulative properties. The major component of aloe vera (AV) gel is acemannan, which has been found to have osteogenic properties. The aim of the present study is to explore the effectiveness of 1% ALN and AV gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients with class II furcation defects. METHODS: Ninety volunteers were randomly assigned to three treatment groups: (a) SRP plus placebo gel; (b) SRP plus 1% ALN gel; and (c) SRP plus AV gel. Clinical and radiographic parameters were recorded at baseline and at 6 and 12 months. RESULTS: The mean probing depth reduction and relative horizontal clinical attachment level (CAL) and relative vertical CAL gains were greater in the ALN group than in the AV and placebo groups at 6 and 12 months. Furthermore, a significantly greater mean percentage of defect depth reduction (DDR) was found in the ALN group (38.09 ± 9.53, 44.86 ± 6.29) than the AV groups (11.94 ± 15.10, 14.59 ± 25.49) at 6 and 12 months, respectively. CONCLUSION: ALN showed significant improvement in all clinical parameters, along with greater DDR, compared to AV in the treatment of class II furcation defects as an adjunct to SRP. © 2018 John Wiley & Sons Australia, Ltd. KEYWORDS: alendronate; aloe vera; clinical trial; furcation defect; periodontal regeneration