Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.

Molecules. 2018 Jul 17;23(7). pii: E1751. doi: 10.3390/molecules23071751. Sharifi-Rad M1, Fokou PVT2, Sharopov F3, Martorell M4, Ademiluyi AO5, Rajkovic J6, Salehi B7,8, Martins N9,10, Iriti M11, Sharifi-Rad J12,13. Author information 1 Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran. mehdi_sharifirad@yahoo.com. 2 Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde Po.Box 812, Cameroon. tsouh80@yahoo.fr. 3 Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan. shfarukh@mail.ru. 4 Nutrition and Dietetics Department, School of Pharmacy, University of Concepción, Concepción 4070386, VIII⁻Bio Bio Region, Chile. mmartorell@udec.cl. 5 Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria. ademiluyidayo@yahoo.co.uk. 6 Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade 11129, Serbia. jolarajkovic@yahoo.com. 7 Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran. bahar.salehi007@gmail.com. 8 Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran. bahar.salehi007@gmail.com. 9 Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal. ncmartins@med.up.pt. 10 Institute for Research and Innovation in Health (i3S), University of Porto⁻Portugal, Porto 4200-135, Portugal. ncmartins@med.up.pt. 11 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy. marcello.iriti@unimi.it. 12 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran. javad.sharifirad@gmail.com. 13 Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada. javad.sharifirad@gmail.com. Abstract In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed. KEYWORDS: Helicobacter pylori; bioactive phytochemicals; gastric cancer; herbal remedies; peptic ulcer; traditional healing systems PMID: 30018251 DOI: 10.3390/molecules23071751 Free full text