Zoonoses Public Health. 2018 Dec;65(8):957-971. doi: 10.1111/zph.12515. Epub 2018 Sep 5.
Murphy CP1,2, Carson C2, Smith BA3, Chapman B3,4, Marrotte J2,4, McCann M2,4, Primeau C2,4, Sharma P2,4, Parmley EJ2.
Author information
- 1
- Natural Sciences and Engineering Research Council Visiting Fellow, Centre for Food-borne, Environmental and Zoonotic Infectious Disease, Public Health Agency of Canada, Guelph, Ontario, Canada.
- 2
- Centre for Food-borne, Environmental and Zoonotic Infectious Disease, Public Health Agency of Canada, Guelph, Ontario, Canada.
- 3
- Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada.
- 4
- Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada.
Abstract
Antimicrobial
resistance is a complex issue with a large volume of published
literature, and there is a need for synthesis of primary studies for an
integrated understanding of this topic. Our research team aimed to have a
more complete understanding of antimicrobial resistance in Canada
(IAM.AMR Project) using multiple methods including the literature
reviews and quantitative modelling. To accomplish this goal, qualitative
features of publications (e.g., geographical location, study
population) describing potential relationships between the occurrence of
antimicrobial resistance and factors (e.g., antimicrobial use;
management system) were of particular interest. The objectives of this
review were to (a) describe the available peer-reviewed literature
reporting potential relationships between factors and antimicrobial
resistance; and (b) to highlight data gaps. A comprehensive literature
search and screening were performed to identify studies investigating
factors potentially linked with antimicrobial resistance in
Campylobacter species, Escherichia coli and Salmonella enterica along
the farm-to-fork pathway (farm, abattoir (slaughter houses) and retail
meats) for the major Canadian livestock species (beef cattle,
broiler chicken and pigs). The literature search returned 14,966
potentially relevant titles and abstracts. Following screening of
titles, abstracts and full-text articles, the qualitative features of
retained studies (n = 28) were extracted. The most common factors
identified were antimicrobial use (n = 13 studies) and type of farm
management system (e.g., antibiotic-free, organic;
n = 8). Most studies were conducted outside of Canada and involved
investigations at the farm level. Identified data gaps included the
effect of vaccination, industry-specific factors (e.g., livestock
density) and factors at sites other than farm along the agri-food
chain. Further investigation of these factors and other relevant
industry activities are needed for the development of quantitative
models that aim to identify effective interventions to mitigate the
occurrence of antimicrobial resistance along the agri-food chain.
KEYWORDS:
Campylobacter ; Escherichia coli ; Salmonella enterica ; bacterial; drug resistance- PMID:
- 30187682
- DOI:
- 10.1111/zph.12515
