Ugwu MELVIN Nnaemeka
Abstract and figures
Several
parts of Cajanus cajan have been utilized traditionally in Eastern
Nigeria in treatment and management of several ailments such as liver,
heart and kidney related diseases. This present research was carried out
to examine the effect of oral administration of aqueous extract of
fresh leaves of Cajanus cajan on creatinine, urea and uric acid
concentrations in albino rats. The research was performed with
twenty-five adult male albino rats distributed into five groups (A, B,
C, D and E) with five rats in each group. The animals in groups A, B, C
and D were administered orally with aqueous extract of fresh leaves of
Cajanus cajan using doses of 150,300, 450 and 600mg/kg respectively for
seven consecutive days, while group E served as the control. There was a
decrease in physical activities and rate of feed and water intake in
the test groups when compared with the control. There was a significant
decrease (P< 0.05) in concentrations of creatinine, urea and uric
acid in the animals given the extract when compared to the control
group. These effects were found to be dose dependent. The result
obtained from this research suggests that aqueous extract of fresh
leaves of Cajanus cajan possess the potential to lower serum
concentration of creatinine, urea and uric acid. This may be responsible
for the utilization of the leaves of Cajanus cajan in management and
treatment of kidney related diseases.
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