Tuesday, 4 October 2016

Hepatoprotective effect of quercetin: From chemistry to medicine.

2016 Aug 31. pii: S0278-6915(16)30308-8. doi: 10.1016/j.fct.2016.08.034. [Epub ahead of print]

Author information

  • 1Department of Zoology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India. Electronic address:
  • 2Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Białystok, ul. Mickiewicza 2a, 15-230, Białystok, Poland.
  • 3Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 1 Chodzki Str., 20-093, Lublin, Poland.
  • 4Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
  • 5Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
  • 6Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:
  • 7Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • 8Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.


Liver diseases caused by viral hepatitis infections have a negative impact on global health. Approximately 30 million people in the USA and 29 million people in the European Union suffer from chronic liver disease. There are many kinds of diseases of the liver, caused by viruses, such as hepatitis A, hepatitis B and hepatitis C, or by certain drugs and poisons including excessive alcohol consumption. Many herbal medicines are used in traditional medicine for their protective and therapeutic properties against liver diseases. Among their bioactive components, flavonoids have been found to be active against liver dysfunction and damage caused by liver diseases. Extensive evidences report that quercetin (QE), a major flavonol commonly found in apple, berries, onion, citrus fruits, cruciferous vegetables, tea, pepper, tomato, whole gain, cocoa and red wine, displays a wide range of healthy properties, including anti-oxidative, anti-inflammatory, anti-apoptotic and hepatoprotective activities against various hepatic ailments. This review aims to critically analyze the available literature regarding the hepatoprotective effects of QE with special emphasis on its mechanisms of actions. To provide a complete picture of QE, its distribution, chemistry, biosynthesis and bioavailability are reported. Overall, data in literature shows that QE appears to be a promising hepatoprotective compound.
Copyright © 2016 Elsevier Ltd. All rights reserved.


Flavonoid; Hepatoprotection; Liver diseases; Oxidative stress; Quercetin
[PubMed - as supplied by publisher]