Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection.

Front Pharmacol. 2016 Jun 17;7:170. doi: 10.3389/fphar.2016.00170. eCollection 2016.

Zaia MG¹, Cagnazzo Td¹, Feitosa KA¹, Soares EG², Faccioli LH³, Allegretti SM⁴, Afonso A⁵, Anibal Fde F¹.

• ¹Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos São Carlos, Brazil.
• ²Department of Patology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, Brazil.
• ³Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, Brazil.
• ⁴Departamento De Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas Campinas, Brazil.
• ⁵Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São CarlosSão Carlos, Brazil; Medical Parasitology Unit, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaLisbon, Portugal; Bioanalytical, Microfabrication, and Separations Group, Instituto de Química de São Carlos, Universidade de São PauloSão Carlos, Brazil.

Abstract

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological and histological parameters in mice infected with Schistosoma mansoni and treated with an herbal commercial medicine. This drug consists of menthol (30-55%) and menthone (14-32%). A 60 day treatment regimen with the herbal medicine decreased the number of S. mansoni eggs in the feces, liver, and intestine and reduced the number of hepatic granulomas. We observed a reduction of 84% in blood eosinophilia and a decrease in the IL-4 and IL-10 blood levels after treatment. Therefore, we propose that schistosomiasis treatment with this herbal medicine for 60 days has an immunomodulatory and anti-inflammatory action in this animal model for schistosomiasis thus contributing to the decrease in physio pathological effects caused by S. mansoni infection.

KEYWORDS:

Mentha piperita L.; Schistosoma mansoni; anti-inflammatory; immunomodulation; treatment

PMID:

27378927

PMCID:

PMC4911957

DOI:

10.3389/fphar.2016.00170

[PubMed]

Free PMC Article

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