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Tuesday, 6 June 2017

Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile.

 2017 May 11;106(Pt A):8-16. doi: 10.1016/j.fct.2017.05.020. [Epub ahead of print]


Ferreres F1, Duangsrisai S2, Gomes NGM3, Suksungworn R2, Pereira DM3, Gil-Izquierdo A4, Valentão P3, Choowongkomon K5, Andrade PB6.

Author information

1
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. Electronic address: federico@cebas.csic.es.
2
Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies in Tropical Natural Resources, NRU-KU, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
3
REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
4
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain.
5
Department of Biochemistry, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand.
6
REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal. Electronic address: pandrade@ff.up.pt.

Abstract

Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported. Regarding potential anti-inflammatory properties, the methanolic extract of the stem bark significantly reduced the levels of NO in macrophages, which may be a consequence of scavenging effect upon •NO. Significant inhibition of phospholipase A2 activity was also noted. Consequently, the therapeutic applicability of this edible plant is also broadened due to the anti-inflammatory properties found.
Copyright © 2017 Elsevier Ltd. All rights reserved.

KEYWORDS:

Apigenin; C-rhamnosyl flavones; Chrysoeriol; Inflammation; Luteolin; Polyphenols
PMID:
 
28502822
 
DOI:
 
10.1016/j.fct.2017.05.020
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