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Wednesday, 21 June 2017

Biological properties of propolis extracts: Something new from an ancient product

 2017 Apr 12. pii: S0009-3084(17)30025-7. doi: 10.1016/j.chemphyslip.2017.04.005. [Epub ahead of print]


Zabaiou N1, Fouache A2, Trousson A2, Baron S2, Zellagui A3, Lahouel M4, Lobaccaro JA5.

Author information

1
Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28, place Henri Dunant, BP38, F63001, Clermont-Ferrand, France; Centre de Recherche en Nutrition Humaine d'Auvergne,58 Boulevard Montalembert, F-63009 Clermont-Ferrand, France; Laboratory of Molecular Toxicology, Department of Molecular and Cellular Biology, Faculty of Science, Université Mohamed Seddik Ben Yahia, 18000 Jijel, Algeria.
2
Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28, place Henri Dunant, BP38, F63001, Clermont-Ferrand, France; Centre de Recherche en Nutrition Humaine d'Auvergne,58 Boulevard Montalembert, F-63009 Clermont-Ferrand, France.
3
Laboratory of Biomolecules and Plant Breeding, Université Larbi Ben M'hidi, 04000 Oum El Bouaghi, Algeria.
4
Laboratory of Molecular Toxicology, Department of Molecular and Cellular Biology, Faculty of Science, Université Mohamed Seddik Ben Yahia, 18000 Jijel, Algeria. Electronic address: lahouelmesbah@yahoo.fr.
5
Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28, place Henri Dunant, BP38, F63001, Clermont-Ferrand, France; Centre de Recherche en Nutrition Humaine d'Auvergne,58 Boulevard Montalembert, F-63009 Clermont-Ferrand, France. Electronic address: j-marc.lobaccaro@univ-bpclermont.fr.

Abstract

Natural products are an interesting source of new therapeutics, especially for cancer therapy as 70% of them have botany origin. Propolis, a resinous mixture that honey bees collect and transform from tree buds, sap flows, or other botanical sources, has been used by ethnobotany and traditional practitioners as early in Egypt as 3000 BCE. Enriched in flavonoids, phenol acids and terpene derivatives, propolis has been widely used for its antibacterial, antifungal and anti-inflammatory properties. Even though it is a challenge to standardize propolis composition, chemical analyses have pointed out interesting molecules that also present anti-oxidant and anti-proliferative properties that are of interest in the field of anti-cancer therapy. This review describes the various geographical origins and compositions of propolis, and analyzes how the main compounds of propolis could modulate cell signaling. A focus is made on the putative use of propolis in prostate cancer.
Copyright © 2017 Elsevier B.V. All rights reserved.

KEYWORDS:

Ethanolic extracts; Flavonoids; Propolis; Prostate cancer; Traditional therapy
PMID:
 
28411017
 
DOI:
 
10.1016/j.chemphyslip.2017.04.005
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